Skip to main content

Somatic Hypermutations

  • 99 Accesses

Somatic hypermutations generally occur in a region of one to two kilobases around the rearranged V-J regions of the immunoglobulin genes and very rarely extend into the C (constant) sections. These mutations, usually transitions, and predominantly involving guanine, are most common in the complementarity-determining region (CDR) and the events usually take place in the germinal centers. The preferred hot spots are purine-G-pyrimidine-(A/T) sequences, although not all these sequences are hot spots for mutation. The serine codons AGC and AGT can represent a hot spot but the TCA, TCC, TCG and TCT are not. The codon usage in the CDR region appears to be evolutionarily determined to secure the maximum complementarity to antigens. It is not entirely clear what determines the targeting of the hypermutations to the special area but transcriptional enhancers appear to be involved. Hypermutations are limited to the coding strand and occur in a downstream polarity. Deletions and insertions are...

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-1-4020-6754-9_15859
  • Chapter length: 2 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   1,199.99
Price excludes VAT (USA)
  • ISBN: 978-1-4020-6754-9
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Hardcover Book
USD   1,499.99
Price excludes VAT (USA)

Rights and permissions

Reprints and Permissions

Copyright information

© 2008 Springer Science+Business Media

About this entry

Cite this entry

(2008). Somatic Hypermutations. In: Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6754-9_15859

Download citation