Sigma Factor

Reference work entry

A subunit of DNA-dependent bacterial RNA polymerase, required for the initiation of transcription and for promoter selection. It has been reported that in Bacillus subtilis, the σ factor alone is sufficient for melting the DNA around site −10 of the promoter (Hsu HH et al 2006 Cell 127:317). The documentation of this finding has been, however, questioned (Xin H 2006 Science 314:1669) and the paper was retracted (2007 Cell 128:211).  open promoter complex,  RNA polymerase,  σ

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