SIGLECs (sialic acid recognizing Ig-superfamily lectins, 19q13.3)

Reference work entry
DOI: https://doi.org/10.1007/978-1-4020-6754-9_15597

Immune inhibitory receptors with sialic acid ligands. During evolution, T cell Siglec expression was largely lost from humans while it was retained in apes. This fact explains why human are more at risk by T-cell-mediated diseases, such as AIDS and hepatitis B and C, compared to apes (Nguyen DH et al 2006 Proc Natl Acad Sci USA 103:7765).  sialic acid,  AIDS,  hepatitis

Copyright information

© Springer Science+Business Media 2008