SIGLECs (sialic acid recognizing Ig-superfamily lectins, 19q13.3)

Reference work entry

Immune inhibitory receptors with sialic acid ligands. During evolution, T cell Siglec expression was largely lost from humans while it was retained in apes. This fact explains why human are more at risk by T-cell-mediated diseases, such as AIDS and hepatitis B and C, compared to apes (Nguyen DH et al 2006 Proc Natl Acad Sci USA 103:7765).  sialic acid,  AIDS,  hepatitis

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