Sickle-Cell Anemia

Reference work entry
DOI: https://doi.org/10.1007/978-1-4020-6754-9_15587
A human hereditary disease caused by homozygosity of a recessive mutation(s) or deletions in the hemoglobin β chain gene. Heterozygosity causes the sickle cell trait. Under low oxygen supply, the red blood cells lose their plump appearance and partially collapse into sickle or odd shapes because of the aggregation of the abnormal hemoglobin molecules (see Fig. S55).
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© Springer Science+Business Media 2008