Reference work entry
The shugoshin cohesin keeps sister chromatids together during anaphase I of meiosis. At meiosis I, Rec8, which replaces SCC1/RAD21 in meiosis, mediates the separation of the chromatids in the chromosome arms but keeps cohesion intact around the centromere until meiosis II. In yeast and probably in other eukaryotes as well, shugoshin protects the separation of chromatids from separase cleavage in meiosis I. Shugoshin is associated with serine/threonine protein phosphatase 2A (PP2A) protein in humans. Shugoshin and PP2A protect the separation of chromatids at the centromere. Shugosin probably dephosphprylates cohesin and protects separation at the centromere (see Fig. S52). meiosis I, meiosis II, cohesin, separin; Kitajima TS et al 2006 Nature [Lond] 441:46; Riedel CG et al 2006 Nature [Lond] 441:53.
© Springer Science+Business Media 2008