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Meselson-Radding Model Of Recombination (1975 Proc Natl Acad Sci USA 72:358)

Explains gene conversion (occurring by asymmetric heteroduplex, symmetric heteroduplex DNA) and crossing over occurring from one initiation event as indicated by the data of Ascobolus spore octads. In yeast the aberrant conversion tetrads arise mainly from asymmetric heteroduplexes as suggested by the Holliday model Holliday model). Symmetric heteroduplex covers the same region of two chromatids whereas asymmetric heteroduplex means that the heteroduplex DNA is present in only one chromatid. The heteroduplexes can be genetically detected very easily in asci containing spore octads. In the absence of heteroduplexes, the adjacent (haploid) spores are identical genetically. If the heteroduplex area carries different alleles the two neighboring spores may become different after post-meiotic mitosis. Actually heteroduplexes may be detectable also in yeast (that forms only 4 ascospores) by sectorial colonies arising from single spores. Branch migration indicates that the exchange points...

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Figure M47.

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(2008). Meselson-Radding Model Of Recombination (1975 Proc Natl Acad Sci USA 72:358). In: Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6754-9_10182

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