Encyclopedia of Entomology

2008 Edition
| Editors: John L. Capinera

Fatty Acid Binding Proteins

  • Norbert H. Haunerland
Reference work entry
DOI: https://doi.org/10.1007/978-1-4020-6359-6_3773

The flight muscles of insects usually depend on fatty acids to fuel migratory flight. These fatty acids are obtained prior to migration from the diet and stored as triacylglycerol in the fat body. During flight, the lipids are converted to diacylglycerol that is released into the hemolymph and transported by the lipoprotein lipophorin to the flight muscle. There, diacylglycerol is hydrolyzed, and free fatty acids enter the muscle cell. Once fatty acids have crossed the plasma membrane, they need to move through the hydrophilic cytosol to the mitochondria where β-oxidation takes place. Because fatty acids are only poorly soluble in water, an intracellular mechanism in needed for their transport through the cytosol. Similarly, a transport process is required in the midgut cells, to facilitate the uptake of fatty acids from the diet and their subsequent delivery to the fat body. The intracellular transport of fatty acids is mediated by fatty acid binding proteins (FABPs).

FABPs are...

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References

  1. Haunerland NH (1997) Transport and utilization of lipids in insect flight muscles. Comp Biochem Physiol 117B:475–482Google Scholar
  2. Haunerland NH (1994) Fatty acid binding protein in locust and mammalian muscle. Comparison of structure, function and regulation. Comp Biochem Physiol 109B:199–208Google Scholar
  3. Smith AF, Tsuchida K, Hanneman E, Suzuki TC, Wells MA (1992) Nucleotide, protein isolation, characterization, and cDNA sequence of two fatty acid-binding proteins from the midgut of Manduca sexta larvae. J Biol Chem 267:380–384PubMedGoogle Scholar
  4. Wu Q, Haunerland NH (2001) A novel fatty acid response element controls the expression of the flight muscle FABP gene of the desert locust, Schistocerca gregaria. Eur J Biochem 268:5894–5900PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Norbert H. Haunerland
    • 1
  1. 1.Simon Fraser UniversityBurnabyCanada