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Cardiovascular Behavioral Medicine: Past, Present, and Future

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Handbook of Cardiovascular Behavioral Medicine
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Abstract

Associations between psychosocial factors and disease have been noted for more than two millennia. By the middle of the twentieth century, scientists identified multiple risk factors for cardiovascular disease (CVD). A handful of modifiable risk factors, including psychosocial variables, seem responsible for nearly all CVD morbidity and mortality although the effects of genes on those risk factors are considerable. The interactive role of an atherogenic diet and psychosocial stress on the progression of atherogenesis in nonhuman animals has been demonstrated experimentally as has the decrease in atherosclerosis progression due to psychosocial factors. At present large-scale, longitudinal, population-based observational studies are examining the biobehavioral, psychosocial, and sociocultural factors that influence CVD risk and health outcomes. Increasingly such studies are using sophisticated genomic, biomarker, vascular, and neuroimaging techniques to examine disease processes. Lifestyle and psychosocial interventions decrease CVD vulnerability in high-risk populations and prevent recurrence of myocardial infarction and death. These results need replication in rigorous randomized controlled trials. Cardiovascular behavioral medicine research has undergone substantial growth during the past three decades and has a bright future.

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References

  1. Adams MR, Kaplan JR, Clarkson TB, Koritnik DR (1985) Ovariectomy, social status, and atherosclerosis in cynomolgus monkeys. Arteriosclerosis 5(2):192–200. PMID 3977777

    Article  PubMed  Google Scholar 

  2. Asimov I (1982) Asimov’s biographical encyclopedia of science and technology, 2nd rev edn. Doubleday, Garden City

    Google Scholar 

  3. Badimon JJ, Zaman A, Helft G, Fayad Z, Fuster V (1999) Acute coronary syndromes: pathophysiology and preventive priorities. Thromb Haemost 82:997–1004. PMID 10605815

    Article  PubMed  Google Scholar 

  4. Beekman M, Heijmans BT, Martin NG, Pederson NL, Whitfield JB et al (2002) Heritabilities of apolipoprotein and lipid level in three countries. Twin Res Hum Genet 5:87–97. PMID 11931686

    Article  Google Scholar 

  5. Berkman LF, Blumenthal J, Burg M, Carney RM, Catellier D et al (2003) Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) randomized trial. JAMA 289:3106–3116. PMID 12813116

    Article  PubMed  Google Scholar 

  6. Bernard C (1865/1961) An introduction to the study of experimental medicine (trans: Greene HC). Collier

    Google Scholar 

  7. Bild DE, Bluemke DA, Burke GL, Detrano R, Roux AVD et al (2002) Multi-ethnic study of atherosclerosis: objectives and design. Am J Epidemiol 156:871–881. PMID 12397006

    Article  PubMed  Google Scholar 

  8. Braunwald E (1997) Shattuck lecture – cardiovascular medicine at the turn of the millennium: triumphs, concerns and opportunities. N Engl J Med 337:1360–1369. PMID 9358131

    Article  PubMed  Google Scholar 

  9. Cannon WB (1928) The mechanism of emotional disturbance of bodily functions. N Engl J Med 198:165–172

    Article  Google Scholar 

  10. Cannon WB (1929) Bodily changes in pain, hunger, fear and rage, 2nd edn. Appleton, New York

    Google Scholar 

  11. Cannon WB (1935) Stresses and strains of homeostasis (Mary Scott Newbold Lecture). Am J Med Sci 189:1–14

    Article  Google Scholar 

  12. Clark AM, Hartling L, Vandermeer B, McAlister FA (2005) Secondary prevention program for patients with coronary artery disease: a meta-analysis of randomized control trials. Ann Intern Med 143:659–672. PMID 16263889

    Article  PubMed  Google Scholar 

  13. Coller BS (1997) Platelet GP IIb/IIIa antagonists: the first anti-integrin receptor therapeutics. J Clin Investig 99:1467–1471. PMID 9119988

    Article  PubMed  PubMed Central  Google Scholar 

  14. Crick F (1970) Central dogma of molecular biology. Nature 227:561–563. PMID 4913914

    Article  PubMed  Google Scholar 

  15. Dawber TR, Meadors CF, Moore FE (1951) Epidemiological approaches to heart disease: the Framingham Study. Am J Public Health 41:279–290. PMID 14819398

    Article  Google Scholar 

  16. Deanfield JE, Halcox JP, Rabelink TJ (2007) Endothelial function and dysfunction: testing and clinical relevance. Circulation 115(10):1285–1295. PMID 17353456

    Article  PubMed  Google Scholar 

  17. deGeus EJC, Kupper N, Boomsma DI, Snider H (2007) Bivariate genetic modeling of cardiovascular stress reactivity: does stress uncover genetic variance? Psychosom Med 69:356–364. PMID 17510291

    Article  Google Scholar 

  18. Descartes R (1637/1956) Discourse on method (trans: LaFleur LJ). Sammes

    Google Scholar 

  19. Dong M, Giles WH, Felitti VJ, Dube SR, Williams JE et al (2004) Insights into causal pathways for ischemic heart disease: adverse childhood experiences study. Circulation 110:1761–1766. Get PMID #

    Article  PubMed  Google Scholar 

  20. Dusseldorp E, van Elderen T, Maes S, Meulman J, Kraaij V (1999) A meta-analysis of psychoeducational programs for coronary heart disease patients. Health Psychol 18:506–519. PMID 10519467

    Article  PubMed  Google Scholar 

  21. Engel GL (1977) The need for a new medical model: a challenge for biomedicine. Science 196(4286):129–136. PMID 847460

    Article  PubMed  Google Scholar 

  22. Frasure-Smith N, Lespérance F, Talajic M (1993) Depression following myocardial infarction. Impact on 6-month survival. JAMA 270:1819–1825. PMID 8411525

    Article  PubMed  Google Scholar 

  23. Frasure-Smith N, Lesperance F, Prince R, Verrier P, Garber RA et al (1997) Randomized trial of home-based psychosocial nursing intervention for patients recovering from myocardial infarction. Lancet 350:473–479. PMID 9274583

    Article  PubMed  Google Scholar 

  24. Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL et al (2007) A second generation human haplotype map of over 3.1 million SNPs. Nature 449:851–861. PMID 17943122

    Article  PubMed  Google Scholar 

  25. Friedman M, Thoresen CE, Gill JJ, Ulmer D, Powell LH, Price VA, Brown B, Thompson L, Rabin DD, Breall WS et al (1986) Alteration of Type A behavior and its effect on cardiac recurrences in post myocardial infarction patients: summary results of the Recurrent Coronary Prevention Project. Am Heart J 112:653–665. PMID 3766365

    Article  PubMed  Google Scholar 

  26. Friedman GD, Cutter GR, Donahue RP, Hughes GH, Hulley SB et al (1988) CARDIA: study design, recruitment and some characteristics of the examined subjects. J Clin Epidemiol 41:1105–1116. PMID 3204420

    Article  PubMed  Google Scholar 

  27. Gallo LC, Troxel WM, Kuller LH, Sutton-Tyrrell K, Edmundowicz D et al (2003) Marital status, marital quality, and atherosclerotic burden in postmenopausal women. Psychosom Med 65:952–962. PMID 14645772

    Article  PubMed  Google Scholar 

  28. Gianaros PJ, Hariri AR, Sheu LK, Muldoon MF, Sutton-Tyrrell K et al (2009) Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdala. Biol Psychiatry 65:943–950. PMID 19013557

    Article  PubMed  Google Scholar 

  29. Gulliksson M, Burell G, Vessby B, Lundin L, Toss H, Svärdsudd K (2011) Randomized controlled trial of cognitive behavioral therapy vs standard treatment to prevent recurrent cardiovascular events in patients with coronary heart disease: secondary prevention in Uppsala primary health care project (SUPRIM). Arch Intern Med 171:134–140. PMID 21263103

    Article  PubMed  Google Scholar 

  30. Harvey W (1628) Exercitatio anatomica de motu cordis et sanguinis in animalibus (Anatomical exercise on the motion of the heart and blood in animals)

    Google Scholar 

  31. Hennekens CH (1998) Increasing burden of cardiovascular disease: current knowledge and future directions for research on risk factors. Circulation 97:1095–1102. PMID 9531257

    Article  PubMed  Google Scholar 

  32. Henry JP, Ely DL, Stephens PM, Ratcliffe HL, Santisteban GA, Shapiro AP (1971) The role of psychosocial factors in the development of arteriosclerosis in CBA mice. Observations on the heart, kidney and aorta. Atherosclerosis 14(2):203–218. PMID: 5165781

    Article  PubMed  Google Scholar 

  33. Humphries SE, Talmud PJ, Hawe E, Bolla M, Day INM et al (2001) Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study. Lancet 358:115–119. PMID 11463413

    Article  PubMed  Google Scholar 

  34. Jialai I (1993) Evolving lipoprotein risk factors: lipoprotein and oxidized low-density lipoprotein. Clin Chem 44:1927–1832

    Google Scholar 

  35. Jones DA, West RR (1996) Psychological rehabilitation after myocardial infarction: multicentre randomized controlled trial. BMJ 313:1517–1521. PMID 8978226

    Article  PubMed  PubMed Central  Google Scholar 

  36. Kannel WB, Dawber TR, Kagan A, Revotskie N, Stokes J III (1961) Factors of risk in the development of coronary heart disease– follow-up experience. The Framingham Study. Ann Intern Med 55:33–50. PMID 13751193

    Article  PubMed  Google Scholar 

  37. Kaplan JR, Manuck SB, Clarkson TB, Lusso FM, Taub DM (1982) Social status, environment, and atherosclerosis in cynomolgus monkeys. Arteriosclerosis 2(5):359–368. PMID 6889852

    Article  PubMed  Google Scholar 

  38. Kaplan JR, Adams MR, Clarkson TB, Koritnik DR (1984) Psychosocial influences on female ‘protection’ among cynomolgus macaques. Atherosclerosis 53(3):283–295. PMID 6543317

    Article  PubMed  Google Scholar 

  39. Kaplan JR, Manuck SB, Adams MR, Weingand KW, Clarkson TB (1987) Inhibition of coronary atherosclerosis by propranolol in behaviorally predisposed monkeys fed an atherogenic diet. Circulation 76:1364–1372. PMID 3677359

    Article  PubMed  Google Scholar 

  40. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM (2002) Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346(6):393–403. PMID 11832527

    Article  PubMed  Google Scholar 

  41. Kumar V, Mitchell R, Fausto N (2007) Robbins basic pathology, 8th edn. Elsevier, Amsterdam

    Google Scholar 

  42. Lang CM (1967) Effects of psychic stress on atherosclerosis in the squirrel monkey (Saimiri sciureus). Proc Soc Exp Biol Med 126:30–34

    Article  Google Scholar 

  43. Lieberman EH, Gerhard MD, Uehata A, Walsh BW, Selwyn AP, Ganz P, Yeung AC, Creager MA (1994) Estrogen improves endothelium-dependent, flow-mediated vasodilation in postmenopausal women. Ann Intern Med 121:936–941. PMID 7978718

    Article  PubMed  Google Scholar 

  44. Linden W, Stossel C, Maurice J (1996) Psychosocial interventions for patients with coronary artery disease. Arch Intern Med 156:745–752. PMID 8615707

    Article  PubMed  Google Scholar 

  45. Linden W, Phillips MJ, Leclerc J (2007) Psychological treatment of cardiac patients: a meta-analysis. Eur Heart J 24:2972–2984. PMID 17984133

    Article  Google Scholar 

  46. Loos RJ (2009) Recent progress in the genetics of common obesity. Br J Clin Pharmacol 68:811–829. PMID 20002076

    Article  PubMed  PubMed Central  Google Scholar 

  47. McCabe PM, Gonzales JA, Zaias J, Szeto A, Kumar M, Herron AL, Schneiderman N (2002) Social environment influences the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Circulation 105:354–359. PMID 11804992

    Article  PubMed  Google Scholar 

  48. McCaffery JM, Pogue-Geile MF, Ferrell RE, Petro N, Manuck SB (2002) Variability within alpha- and beta-adrenoreceptor genes as a predictor of cardiovascular function at rest and in response to mental challenge. J Hypertens 20:1105–1114. PMID 12023679

    Article  PubMed  Google Scholar 

  49. Middledorp CM, Birley AJ, Cath DC, Gillespic NA, Willemsen G et al (2005) Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings. Twin Res Hum Genet 8:609–615. PMID 16354503

    Article  Google Scholar 

  50. Moher D, Schulz KF, Altman D (2001) The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. JAMA 285:1987–1991. PMID 11308435

    Article  PubMed  Google Scholar 

  51. Nerem RM, Levesque MJ, Cornhill JF (1980) Social environment as a factor in diet-induced atherosclerosis. Science 208(4451):1475–1476. PMID 7384790

    Article  PubMed  Google Scholar 

  52. Nolte IM, McCaffery JM, Snieder H (2010) Candidate gene and genome-wide association studies in behavioral medicine. In: Steptoe A (ed) Handbook of behavioral medicine: methods and applications. Springer, New York

    Google Scholar 

  53. Ohara Y, Peterson TE, Harrison DG (1993) Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 91:2546–2551. PMID: 8390482

    Article  PubMed  PubMed Central  Google Scholar 

  54. Ohlin B, Berglund G, Nilsson P, Melander O (2007) Job strain, decision latitude and alpha 2β-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in men. J Hypertens 25:1613–1619. PMID 17620957

    Article  PubMed  Google Scholar 

  55. Orth-Gomér K, Schneiderman N, Wang H, Walldin C, Bloom M, Jernberg T (2009) Stress reduction prolongs life in women with coronary disease: the Stockholm Women’s Intervention Trial for Coronary Heart Disease (SWITCHD). Circ Cardiovasc Qual Outcomes 2:25–32. PMID 20031809

    Article  PubMed  Google Scholar 

  56. Paredes J, Szeto A, Levine JE, Zaias J, Gonzales JA, Mendez AJ, Llabre MM, Schneiderman N, McCabe PM (2006) Social experience influences hypothalamic oxytocin in the WHHL rabbit. Psychoneuroendocrinology 31:1062–1075. PMID 16963189

    Article  PubMed  Google Scholar 

  57. Pasterkamp G, Shoneveld AH, van der Wal AC, Haudenschild CC, Clarijs RJ, Becker AE et al (1998) Relation of arterial geometry to luminal narrowing and histologic markers for plaque vulnerability: the remodeling paradox. J Am Coll Cardiol 32:655–662. PMID 9741507

    Article  PubMed  Google Scholar 

  58. Patten SB (1997) Performance of the Composite International Diagnostic Interview Short Form for major depression in community and clinical samples. Chronic Dis Can 18:109–112. PMID 9375257

    PubMed  Google Scholar 

  59. Porter R (1994) The biographical dictionary of scientists, 2nd edn. Oxford University Press, New York

    Google Scholar 

  60. Ratcliffe HL, Snyder RL (1967) Arteriosclerotic stenosis of the intramural coronary arteries of chickens: further evidence of a relation to social factors. Br J Exp Pathol 48(3):357–365. PMID 6026973

    PubMed  PubMed Central  Google Scholar 

  61. Ridker PM, Hennekens CH, Buring JE, Nader R (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342:836–844. PMID 10733371

    Article  PubMed  Google Scholar 

  62. Rosengren A, Hawken S, Ounpuu S, Silwa K, Zubaid M et al (2004) Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): case-control study. Lancet 364:953–962. PMID 15364186

    Article  PubMed  Google Scholar 

  63. Ross R (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362:801–809. PMID 8479518

    Article  PubMed  Google Scholar 

  64. Ross R, Glomset JA (1973) Atherosclerosis and the arterial smooth muscle cell: proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science 180(93):1332–1339. PMID 4350926

    Article  PubMed  Google Scholar 

  65. Rushmer RF (1989) Structure and function of the cardiovascular system. In: Schneiderman N, Kaufmann P, Weiss SM (eds) Handbook of research methods in cardiovascular behavioral medicine. Plenum, New York

    Google Scholar 

  66. Schneiderman N, Kaufmann P, Weiss SM (eds) (1989a) Handbook of research methods in cardiovascular behavioral medicine. Plenum, New York

    Google Scholar 

  67. Schneiderman N, Chesney MA, Krantz DS (1989b) Biobehavioral aspects of cardiovascular disease: progress and prospects. Health Psychol 8:649–676. PMID 2700341

    Article  PubMed  Google Scholar 

  68. Schoenhagen P, McErlean ES, Nissen SE (2000) The vulnerable coronary plaque. J Cardiovasc Nurs 15:1–12. PMID: 11061217

    Article  PubMed  Google Scholar 

  69. Schousboe K, Willemsen G, Kyvik KO, Mortensen J, Boomsma DI, Cornes BK et al (2003) Sex differences in heritability of BMI: a comparative study of results from twin studies in eight countries. Twin Res Hum Genet 6:409–421. PMID 14624725

    Article  Google Scholar 

  70. Seyle H (1956) The stress of life. McGraw-Hill, New York

    Google Scholar 

  71. Sorlie PD, Avilés-Santa L, Wassertheil-Smoller S, Kaplan RC, Daviglus ML et al (2010) Design and implementation of the Hispanic Community Health Study/Study of Latinos. Ann Epidemiol 20:629–641. PMID 20609343

    Article  PubMed  PubMed Central  Google Scholar 

  72. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M (2001) Finnish Diabetes Prevention Study Group. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344(18):1343–1350. PMID 11333990

    Article  PubMed  Google Scholar 

  73. van Vliet-Ostaptchouk JV, den Hoed M, Luan J, Zhao KK et al (2013) Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals. Diabetologia 56:2134–2146. PMID: 23827965

    Article  PubMed  Google Scholar 

  74. VanderLaan PA, Reardon CA, Getz GS (2004) Site specificity of atherosclerosis: site-selective responses to atherosclerotic. Arterioscler Thromb Vasc Biol 24:12–22. PMID 14604830

    Article  PubMed  Google Scholar 

  75. Versalius A (1543) De humani corporis fabrica (On the make up of the human body)

    Google Scholar 

  76. Vink JM, Willemsen G, Boomsma DI (2005) Heritability of smoking initiation and nicotine dependence. Behav Genet 35:397–406. PMID 15971021

    Article  PubMed  Google Scholar 

  77. Virchow RLK (1856) Thrombose und Embolie. Gefässentzündung und septische Infektion. In: Gesammelte Abhandlungen zur wissenschaftlichen Medicin. Von Meidinger & Sohn, Frankfurt am Main, pp 219–732. Translation in Matzdorff AC, Bell WR (1998) Thrombosis and embolie (1846–1856). Canton, Massachusetts: Science History Publications. ISBN 0-88135-113-X

    Google Scholar 

  78. Whipple MO, Lewis TT, Sutton-Tyrrell K, Matthews KA, Barinas-Mitchell E et al (2009) Hopelessness, depressive symptoms, and carotid atherosclerosis in women the study of women’s health across the national (SWAN) heart study. Stroke 40:3166–3172. PMID 19713542

    Article  PubMed  PubMed Central  Google Scholar 

  79. Williams RB, Marchuk DA, Siegler IC, Barefoot JC, Helms MJ et al (2008) Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress. Psychosom Med 70:32–39. PMID 18158371

    Article  PubMed  Google Scholar 

  80. Wing RR, Bahnson JL, Bray GA, Clark JM et al (2010) Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus. Arch Intern Med 170:1566–1575. Look AHEAD trial. PMID 20876408

    PubMed  Google Scholar 

  81. Wing RR, Bolin P, Brancati FL, Bray G et al (2013) Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med 39:145–154. PMCID: 23796131 PMC3791615

    Google Scholar 

  82. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L, INTERHEART Study Investigators (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 364:937–952. PMID 15364185

    Article  PubMed  Google Scholar 

  83. Zeiher AM, Drexler H, Wollschlager H, Just H (1991) Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis. Circulation 84:1984–1992. 1934373

    Article  PubMed  Google Scholar 

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Schneiderman, N. (2022). Cardiovascular Behavioral Medicine: Past, Present, and Future. In: Waldstein, S.R., Kop, W.J., Suarez, E.C., Lovallo, W.R., Katzel, L.I. (eds) Handbook of Cardiovascular Behavioral Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-85960-6_1

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