Synonyms
Glioma-infiltrating macrophages; TIMs; Tumor-infiltrating macrophages/microglia
Definition
Inflammatory cells of monocytic lineage present in the neoplastic environment of central nervous system glial tumors.
Basic Characteristics
Introduction
Glioblastoma is a high-grade glial tumor that has remained one of the deadliest human malignancies despite decades of basic scientific and clinical research. In the United States alone, this disease is diagnosed in approximately 10,000 patients per year, and the median survival of newly diagnosed glioblastoma following surgery, radiation, and chemotherapy is about 1 year (Louis et al. 2007). Particularly as new therapeutic avenues are sought, there has been increasing interest in leveraging the patient’s own innate and adaptive immune responses in the fight against glial tumors.
The central nervous system (CNS) has a unique relationship with the immune system that sets it apart from all other organ systems in the body. Notable features...
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References
Badie B, Schartner J. Role of microglia in glioma biology. Microsc Res Tech. 2001;54:106–13.
Carpentier AF, Auf G, Delattre JY. CpG-oligonucleotides for cancer immunotherapy: review of the literature and potential applications in malignant glioma. Front Biosci. 2003;8:e115–27.
Chin L, Meyerson M, et al. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008; 455:1061–1068.
Graeber MB, Scheithauer BW, Kreutzberg GW. Microglia in brain tumors. Glia. 2002;40:252–9.
Hussain SF, Yang D, Suki D, Aldape K, Grimm E, Heimberger AB. The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. Neuro Oncol. 2006;8:261–79.
Louis DN, Ohgaki H, Wiestler OD, Cavanee WK (2007) WHO classification of tumours of the central nervous system. Lyon, France: International Agency for Research on Cancer (IARC); vol 4th edn.
Morimura T, Neuchrist C, Kitz K, Budka H, Scheiner O, Kraft D, Lassmann H. Monocyte subpopulations in human gliomas: expression of Fc and complement receptors and correlation with tumor proliferation. Acta Neuropathol. 1990;80:287–94.
Yang I, Han SJ, Kaur G, Crane C, Parsa AT. The role of microglia in central nervous system immunity and glioma immunology. J Clin Neurosci. 2010;17:6–10.
Zhang L, Alizadeh D, Van Handel M, Kortylewski M, Yu H, Badie B. Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice. Glia. 2009;57:1458–67.
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Pisapia, D., Lavi, E. (2014). Tumor Macrophages. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_9
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DOI: https://doi.org/10.1007/978-0-387-84828-0_9
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