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Adaptive Immune Cells in the Liver

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Encyclopedia of Medical Immunology

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Synonyms

Hepatic adaptive immune cells

Definition

The adaptive immune cells of liver includes T cells and B cells, and they possess specificity, diversity, and immunological memory. These cells recognize specific antigenic epitopes. T lymphocytes provide cell-mediated immunity and consist of CD8+ cytotoxic T lymphocytes (Tc) and CD4+ T helper lymphocytes (Th). B lymphocytes are characterized by the production of antibodies raised against specific antigens and participate in humoral immunity. They orchestrate a major role of in both immunity and tolerance in the liver along with other immune cells.

The cardinal features of the adaptive immune system are specificity, diversity, and immunological memory. The adaptive (specific) immune response is orchestrated by T lymphocytes and B lymphocytes, which recognize specific antigenic epitopes. It has immunological memory in that a subsequent exposure to the same antigen leads to a more rapid, sustained, and potent immune response. T...

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Authors and Affiliations

  1. Centre for Liver Research & NIHR BRU, Institute of Biomedical Research, University of Birmingham Medical School & UHB NHS Foundation Trust, College of Medical and Dental Sciences, Wolfson Drive, Edgbaston, Birmingham, UK

    Ye Htun Oo & David H. Adams

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  1. Ye Htun Oo
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  2. David H. Adams
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Correspondence to David H. Adams .

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Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Betty Diamond

  4. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Anne Davidson

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Oo, Y.H., Adams, D.H. (2014). Adaptive Immune Cells in the Liver. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_61

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