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Short Description or Definition

The term alexia is applied to acquired disorders of reading produced by neurological injury in individuals with normal premorbid literacy skills. Clinically, patients with alexia have difficulty in recognizing, pronouncing, or comprehending written words. Although alexia can occur in relative isolation, it is more frequently encountered in the context of spoken language dysfunction or aphasia. Most individuals with alexia have concommitant spelling impairment or agraphia, suggesting that reading and spelling rely on shared cognitive representations and neural substrates. Acquired alexia needs to be distinguished from developmental dyslexia reflecting a failure to attain normal reading skills.

Categorization

Alexia is not a single clinical entity. Instead, there are several distinct forms of alexia characterized by specific combinations of impaired and preserved reading abilities and associated with unique lesion profiles. The three most commonly...

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References and Readings

  • Beeson, P. M., & Rapcsak, S. Z. (2006). Treatment of alexia and agraphia. In J. H. Noseworthy (Ed.), Neurological therapeutics: Principles and practice (2nd ed., pp. 3045–3060), London: Martin Dunitz.

    Google Scholar 

  • Beeson, P. M., Rapcsak, S. Z., Plante, E., Chargualaf, J., Chung, A., Johnson, S. C., et al. (2003). The neural substrates of writing: A functional magnetic resonance imaging study. Aphasiology, 17, 647–665.

    Google Scholar 

  • Behrmann, M., Plaut, D. C., & Nelson, J. (1998). A literature review and new data supporting an interactive account of letter-by-letter reading. Cognitive Neuropsychology, 15, 7–51.

    Google Scholar 

  • Binder, J. R., Desai, R. H., Graves, W. W., & Conant, L. L. (2009). Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies. Cerebral Cortex, 19, 2767–2796.

    PubMed Central  PubMed  Google Scholar 

  • Cohen, L., Lehéricy, S., Chochon, F., Lemer, C., Rivaud, S., & Dehaene, S. (2002). Language-specific tuning of visual cortex? Functional properties of the visual word form area. Brain, 125, 1054–1069.

    PubMed  Google Scholar 

  • Cohen, L., Martinaud, O., Lemer, C., Lehéricy, S., Samson, Y., Obadia, M., et al. (2003). Visual word recognition in the left and right hemispheres: Anatomical and functional correlates of peripheral alexias. Cerebral Cortex, 13, 1313–1333.

    PubMed  Google Scholar 

  • Coltheart, M., Patterson, K., & Marshall, J. C. (1980). Deep dyslexia. London: Routledge & Kegan Paul.

    Google Scholar 

  • Coltheart, M., Rastle, K., Perry, C., Langdon, R., & Ziegler, J. (2001). DRC: A dual route cascaded model of visual word recognition and reading aloud. Psychological Review, 108, 204–256.

    PubMed  Google Scholar 

  • Crisp, J., & Lambon Ralph, M. A. (2006). Unlocking the nature of the phonological-deep dyslexia continuum: The keys to reading aloud are in phonology ad semantics. Journal of Cognitive Neuroscience, 18, 348–362.

    PubMed  Google Scholar 

  • Epelbaum, S., Pinel, P., Gaillard, R., Delmaire, C., Perrin, M., Dupont, S., et al. (2008). Pure alexia as a disconnection syndrome: New diffusion imaging evidence for an old concept. Cortex, 44, 962–974.

    PubMed  Google Scholar 

  • Galton, C. J., Patterson, K., Graham, K., Lambon Ralph, M. A., Williams, G., Antoun, N., et al. (2001). Differing patterns of temporal atrophy in Alzheimer’s disease and semantic dementia. Neurology, 57, 216–225.

    PubMed  Google Scholar 

  • Graham, N. L., Patterson, K., & Hodges, J. R. (2000). The impact of semantic memory impairment on spelling: Evidence from semantic dementia. Neuropsychologia, 38, 143–163.

    PubMed  Google Scholar 

  • Jobard, G., Crivello, F., & Tzourio-Mazoyer, N. (2003). Evaluation of the dual route theory of reading: A metaanalysis of 35 neuroimaging studies. NeuroImage, 20, 693–712.

    PubMed  Google Scholar 

  • Kay, J., Lesser, R., & Coltheart, M. (1992). Psycholinguistic assessments of language processing in aphasia (PALPA). East Sussex, England: Lawrence Erlbaum Associates.

    Google Scholar 

  • Mummery, C. J., Patterson, K., Price, C. J., Ashburner, J., Frackowiak, R. S. J., & Hodges, J. R. (2000). A voxel-based morphometry study of semantic dementia: Relationship between temporal lobe atrophy and semantic memory. Annals of Neurology, 47, 36–45.

    PubMed  Google Scholar 

  • Patterson, K., Graham, N., & Hodges, J. R. (1994). Reading in dementia of the Alzheimer type: A preserved ability? Neuropsychology, 8, 835–407.

    Google Scholar 

  • Patterson, K., & Lambon Ralph, M. A. (1999). Selective disorders of reading? Current Opinion in Neurobiology, 9, 235–239.

    PubMed  Google Scholar 

  • Patterson, K. E., Marshall, J. C., & Coltheart, M. (1985). Surface dyslexia: Neuropsychological and cognitive studies of phonological reading. London: Lawrence Erlbaum.

    Google Scholar 

  • Plaut, D. C., McClelland, J. L., Seidenberg, M. S., & Patterson, K. (1996). Understanding normal and impaired word reading: Computational principles in quasi-regular domains. Psychological Review, 103, 56–115.

    PubMed  Google Scholar 

  • Rapcsak, S. Z., & Beeson, P. M. (2004). The role of left posterior inferior temporal cortex in spelling. Neurology, 62, 2221–2229.

    PubMed  Google Scholar 

  • Rapcsak, S. Z., Beeson, P. M., Henry, M. L., Leyden, A., Kim, E. S., Rising, K., et al. (2009). Phonological dyslexia and dysgraphia: Cognitive mechanisms and neural substrates. Cortex, 45(5), 575–591.

    PubMed Central  PubMed  Google Scholar 

  • Vanier, M., & Caplan, D. (1985). CT correlates of surface dyslexia. In K. E. Patterson, J. C. Marshall, & M. Coltheart (Eds.), Surface dyslexia: Neuropsychological and cognitive studies of phonological reading (pp. 511–525). London: Lawrence Erlbaum.

    Google Scholar 

  • Vigneau, M., Beaucousin, V., Hervé, P. Y., Duffau, H., Crivello, F., Houdé, O., et al. (2006). Meta-analyzing left hemisphere language areas: Phonology, semantics, and sentence processing. NeuroImage, 30, 1414–1432.

    PubMed  Google Scholar 

  • Woollams, A., Lambon Ralph, M. A., Plaut, D. C., & Patterson, K. (2007). SD-squared: On the association between semantic dementia and surface dyslexia. Psychological Review, 114, 316–339.

    PubMed  Google Scholar 

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Rapcsak, S.Z., Beeson, P.M. (2011). Alexia. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-79948-3_852

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  • DOI: https://doi.org/10.1007/978-0-387-79948-3_852

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-79947-6

  • Online ISBN: 978-0-387-79948-3

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