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Secondary-Progressive Multiple Sclerosis

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Encyclopedia of Clinical Neuropsychology

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Synonyms

Advanced MS

Short Description or Definition

Secondary-progressive multiple sclerosis (SPMS) describes a more advanced disease stage of individuals who initially experience a relapsing–remitting course (RRMS). Typically, there are no or few discrete episodes of neurological dysfunction (i.e., relapses), and there is continued accumulation of neurological deficits resulting in increasing disability (see Figs. 1 and 2). The transition from a relapsing–remitting course to secondary progression can be subtle initially, and thus is often diagnosed in retrospect following a 6–12-month period of sustained progression. To date, no clear biological markers have been found to indicate the point at which the course of MS changes.

Secondary-Progressive Multiple Sclerosis. Figure 1
figure 191 figure 191

Secondary-progressive multiple sclerosis. Note: Disease course starts as relapsing–remitting but over time relapses no longer occur and there is a continuous worsening of symptoms and accumulation of disability....

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Authors and Affiliations

  1. Department of Neurology, University of Virginia Health System, 800394, 22908-0394, Charlottesville, VA, USA

    Kathleen Fuchs

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  1. Kathleen Fuchs
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Editors and Affiliations

  1. Physical Medicine and Rehabilitation, and Professor of Neurosurgery, and Psychiatry Virginia Commonwealth University – Medical Center Department of Physical Medicine and Rehabilitation, VCU, 980542, Richmond, Virginia, 23298-0542, USA

    Jeffrey S. Kreutzer

  2. Kessler Foundation Research Center, 1199 Pleasant Valley Way, West Orange, NJ, 07052, USA

    John DeLuca

  3. Professor of Physical Medicine and Rehabilitation, and Neurology and Neuroscience, University of Medicine and Dentistry of New Jersey – New Jersey Medical School, New Jersey, USA

    John DeLuca

  4. Independent Practice, 564 M.O.B. East, 100 E. Lancaster Ave., Wynnewood, PA, 19096, USA

    Bruce Caplan

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Fuchs, K. (2011). Secondary-Progressive Multiple Sclerosis. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-79948-3_519

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  • DOI: https://doi.org/10.1007/978-0-387-79948-3_519

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