Synonyms
Definition
The blood-brain barrier (BBB) maintains brain homeostasis by regulating the movement of compounds across the endothelium of cerebral capillaries.
Current Knowledge
BBB serves to maintain brain homeostasis by regulating the influx and efflux of compounds to and from the brain. The presence of a barrier was first documented by Paul Ehrlich in the late nineteenth century. However, it was not until the advent of the electron microscope that the makeup of the BBB was begun to be understood. The brain microvascular endothelium comprises the BBB. In contrast to endothelium from other vascular beds, the morphologic features unique to the brain microvascular endothelium, such as tight junctions, increased electrical resistance, and lack of pinocytic vesicles, provide limited and selective access to this highly specialized organ. Only lipophilic molecules less than 600 Da can passively diffuse through the BBB. This protects the brain from toxins,...
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsAuthor information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this entry
Cite this entry
Tran, N. (2011). Blood-Brain Barrier. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-79948-3_299
Download citation
DOI: https://doi.org/10.1007/978-0-387-79948-3_299
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-79947-6
Online ISBN: 978-0-387-79948-3
eBook Packages: Behavioral Science