Proposed Mechanism(s) of Action
Amoxapine inhibits reuptake of norepinephrine and noradrenaline. It is also known to antagonize Serotonin 2A receptors, thus increasing presynaptic release of amines. Mild Dopamine 2 blockade.
Reactive depressive disorder, psychotic depression, and depression accompanied by anxiety or agitation.
Off Label Use
Depressive phase of a bipolar disorder, anxiety, insomnia, neuropathic pain, and treatment resistant depression.
Paralytic ileus, hyperthermia, lowered seizure threshold, sudden death, cardiac arrhythmias, tachycardia, QTc prolongation, hepatic failure, intraocular pressure, mania, and potential for activation of suicidal ideation.
Blurred vision, constipation, urinary retention, increased appetite, dry mouth, diarrhea, heartburn, weight gain, fatigue, weakness, dizziness, anxiety, sexual dysfunction, sweating, rash, and itching. Can...
References and Readings
- Physicians’ Desk Reference (62nd ed.). (2007). Montvale, NJ: Thomson PDR.Google Scholar
- Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York, NY: Cambridge University Press.Google Scholar
- Drug Interaction Effects: http://www.drugs.com/drug_interactions.html
- Drug Molecule Images: http://www.worldofmolecules.com/drugs/
- Free Drug Online and PDA Software: www.epocrates.com
- Gene-Based Estimate of Drug interactions: http://mhc.daytondcs.com: 8080/cgi bin/ddiD4?ver=4&task=getDrugList
- Pill Identification: http://www.drugs.com/pill_identification.html