Encyclopedia of Clinical Neuropsychology

2011 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • John C. Courtney
Reference work entry
DOI: https://doi.org/10.1007/978-0-387-79948-3_1625

Generic Name


Brand Name



Tricyclic Antidepressant

Proposed Mechanism(s) of Action

Increases available norepinephrine and serotonin, blocks serotonin reuptake and may desensitize both serotonins 1A and beta adrenergic receptors.



Off Label Use

Neuropathic pain, fibromyalgia, headache, and insomnia

Side Effects


Paralytic ileus, hyperthermia, lowered seizure threshold, sudden death, cardiac arrhythmias, tachycardia, QTc prolongation, hepatic failure, mania, potential for activation of suicidal ideation


Blurred vision, constipation, urinary retention, increased appetite, dry mouth, diarrhea, heartburn, weight gain, fatigue, weakness, dizziness, anxiety, sexual dysfunction, sweating, rash, and itching

References and Readings

  1. Physicians’ Desk Reference (62nd ed.). (2007). Montvale, NJ: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York, NY: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software: www.epocrates.com

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • John C. Courtney
    • 1
  1. 1.Department of PsychologyChildren's Hospital of New OrleansNew OrleansUSA