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Development of Novel Pancreatic Tumor Biomarkers

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Pancreatic Cancer

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Abstract:

Pancreatic adenocarcinoma is the fourth leading cause of death due to cancer, with the lowest survival rate of any cancer. There is great interest in identifying and developing useful markers of pancreatic cancer to help detect early stage pancreatic cancer and its precursors. Markers are also needed that could predict response to emerging novel therapies for pancreatic cancer. However, the development of such markers requires well-designed studies that evaluating marker performance in the appropriate clinical settings where the marker would be required. This review discusses commonly used approaches to discover new cancer markers and how to design and evaluate studies of pancreatic cancer markers.

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Abbreviations

BEAMing:

Beads, Emulsion, Amplification and Magnetics

ERCP:

endoscopic retrograde cholangiopancreatography

EUS:

endoscopic ultrasound

FNA:

fine needle aspiration

IPMN:

Intraductal papillary mucinous neoplasm

MCNs:

mucinous cystic neoplasms

miRNAs:

microRNAs

MSP:

methylation-specific PCR

PanIN:

Pancreatic intraepithelial neoplasia

RT-PCR:

reverse transcriptase-polymerase chain reaction

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Acknowledgment

This work was supported by the National Cancer Institute grant (CA120432, CA62924), the V foundation, the Lustgarten Foundation for Pancreatic Cancer Research and the Michael Rolfe Foundation.

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  1. Departments of Medicine, Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA

    Michael Goggins

  2. Director of the Pancreatic Cancer Early Detection Laboratory, Cancer Research Building, Baltimore, MD, USA

    Michael Goggins

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Goggins, M. (2010). Development of Novel Pancreatic Tumor Biomarkers. In: Pancreatic Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77498-5_50

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