Encyclopedia of Microfluidics and Nanofluidics

2008 Edition
| Editors: Dongqing Li

Microfluidic Devices in Tissue Engineering

  • Palaniappan Sethu
  • Robert S. Keynton
Reference work entry
DOI: https://doi.org/10.1007/978-0-387-48998-8_933


Cell and tissue culture; Microfluidic platforms; Cellular microenvironments; Microfluidic cell culture; Organ fabrication; Organ or tissue augmentation


Tissue Engineering

Tissue engineering collectively refers to efforts used to augment, repair or replace tissue or organ using cellular substitutes that have appropriate structural organization and function behavior. This is a highly inter disciplinary field and has received significant contributions from researchers from various fields of engineering and life sciences. Several interpretations of phrase tissue engineering exist today, including commonly used definitions coined by Skalak and Fox

“Tissue engineering is the application of the principles and methods of engineering and the life science toward the fundamental understanding of structure-function relationships in normal and pathological mammalian tissue and the development of biological substitutes to restore, maintain or improve functions,”

Langer and Vacanti
This is a preview of subscription content, log in to check access.


  1. 1.
    Andersson H, van den Berg A (2004) Microfabrication and microfluidics for tissue engineering: state of the art and future opportunities. Lab Chip 4(2):98–103 Google Scholar
  2. 2.
    Bhatia SN, Balis UJ et al (1999) Effect of cell–cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells. FASEB J 13(14):1883–1900 Google Scholar
  3. 3.
    Boland T, Xu T, Damon B, Cui X (2006) Application of inkjet printing to tissue engineering. Biotechn J 1(9):910–917 Google Scholar
  4. 4.
    Borenstein JT, Terai H, King KR, Weinberg EJ, Kaazempur-Mofrad MR, Vacanti JP (2002) Microfabrication Technology for Vascularized Tissue Engineering. Biomed Microdev 4(3):167–175 Google Scholar
  5. 5.
    Erickson D, Li D (2004) Integrated microfluidic devices. Anal Chim Acta 507(1):11–26 Google Scholar
  6. 6.
    Folch A, Toner M (2000) Microengineering of cellular interactions. Ann Rev Biomed Eng 2:227–256 Google Scholar
  7. 7.
    Kane RS, Takayama S, Ostuni E, Ingber DE, Whitesides GM (1999) Patterning proteins and cells using soft lithography. Biomaterials 20(23–24):2363–76 Google Scholar
  8. 8.
    Lucchetta EM, Lee JH et al (2005) Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics. Nature 434(7037):1134–1138 Google Scholar
  9. 9.
    Parker KK, Brock AL et al (2002) Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. FASEB J 16(10):1195–1204 Google Scholar
  10. 10.
    Tourovskaia A, Figueroa-Masot X, Folch A (2005) Differentiation-on-a-chip: a microfluidic platform for long-term cell culture studies. Lab Chip 5(1):14–9 Google Scholar
  11. 11.
    Zeringue HC, Rutledge JJ, Beebe DJ (2005) Early mammalian embryo development depends on cumulus removal technique. Lab Chip 5(1):86–90 Google Scholar
  12. 12.
  13. 13.
  14. 14.
  15. 15.
  16. 16.
  17. 17.

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Palaniappan Sethu
    • 1
  • Robert S. Keynton
    • 1
  1. 1.Department of BioengineeringUniversity of LouisvilleLouisvilleUSA