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Handbook of Neurochemistry and Molecular Neurobiology pp 1–16Cite as

Cortical Dopamine in Schizophrenia

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Abstract:

This chapter is a review of the evidence implicating a dysfunction of dopamine transmission in the prefrontal cortex in schizophrenia, underlying negative symptoms and cognitive deficits. The evidence derives essentially from brain imaging studies, post-mortem studies and clinical pharmacological studies. The imaging studies have suggested alterations in the main mediator of dopamine transmission in the cortex, the D1 receptors. Furthermore, studies have suggested a link between NMDA deficits and D1 alterations in the cortex in schizophrenia, suggesting that therapeutic interventions at these targets may have beneficial effects on cognition and negative symptoms.

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Abbreviations

CKU:

chronic ketamine users

COMT:

catechol-O-methyltransferase

DA:

dopamine

DAT:

DA transporters

DLPFC:

dorsolateral prefrontal cortex

EC:

entorhinal cortex

MPFC:

medial prefrontal cortex

NET:

norepinephrine transporters

PFC:

prefrontal cortex

SN:

substantia nigra

VTA:

ventral tegmental area

TH:

tyrosine hydroxylase

WCST:

Wisconsin Cart Sort Task

WM:

working memory

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Authors
  1. A. Abi-Dargham
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Editors and Affiliations

  1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, 10962, Orangeburg, New York, USA

    Abel Lajtha (Director) (Director)

  2. Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, New York, 10962, USA

    Daniel Javitt (Director) (Director)

  3. Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, New York, 10962, USA

    Joshua Kantrowitz

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© 2009 Springer Science+Business Media, LLC

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Abi-Dargham, A. (2009). Cortical Dopamine in Schizophrenia. In: Lajtha, A., Javitt, D., Kantrowitz, J. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30410-6_1

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