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Neuroimmune Cross Talk

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Book cover Handbook of Neurochemistry and Molecular Neurobiology

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Abstract:

Immune system and the nervous system share the job of keeping the homeostatic control and responding to changes in external and internal environment. Similarity of their functions and common use of receptors, ligands and other cell-to-cell communication molecules by cells of nervous and immune system origin supports the idea that the two systems function in close cooperation. This chapter intends to provide an overview of the field of neuroimmune cross talk including innervation of immune system, innate immune system of the brain, commonly used mediators and transmitters, and the similarity of neuronal and immune synapse. We did not focus on autoimmune diseases of the brain and only barely touch the medical neuroimmunology because we aimed to give a survey of basic facts and principles of neuroimmune cross talk, providing a firm background for understanding medical consequences of interaction between the two systems.

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Abbreviations

ACTH:

adrenocorticotropic hormone

APC:

antigen-presenting cell

BDNF:

brain-derived nerve growth factor

CGRP:

Calcitonin gene-related peptide

CRF:

Corticotrophin-releasing factor

CRH:

corticotropin-releasing hormone

ICAM:

integrin-mediated cell adhesion molecules

LPS:

lipopolysaccharides

MAPK:

mitogen-activated protein kinase

MCP-1:

monocyte chemoattractant protein

NCAM:

Neuronal cell adhesion molecules

NOS:

nitric oxide synthase

NGF:

nerve growth factor

PVN:

paraventricular nucleus

RAMP:

receptor activity-modulating protein;

SMAC:

supramolecular activation cluster

TLR:

toll-like receptor

VIP:

vasoactive intestinal polypeptide

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Authors
  1. G. Juhász
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Editors and Affiliations

  1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, 10962, New York, Orangeburg, USA

    Abel Lajtha (Director) (Director)

  2. The Buniatian Institute of Biochemistry the National Academy of Sciences, 5/1 Sevag str., 375014, Yerevan, Republic of Armenia

    Armen Galoyan

  3. Dept. Immunophysiology Medical Faculty, Inst. of Normal and Pathological Physiology, Deutschhausstrase 2, D–35037, Marburg, Germany

    Hugo O. Besedovsky

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Juhász, G. (2008). Neuroimmune Cross Talk. In: Lajtha, A., Galoyan, A., Besedovsky, H.O. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30398-7_13

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