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GFAP and Astrocyte Intermediate Filaments

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Handbook of Neurochemistry and Molecular Neurobiology

Abstract:

This chapter focuses on the role of glial fibrillary acidic protein (GFAP) and other intermediate filament (IF) proteins expressed in astroglial cells under physiological situations and it also discusses their functions in the context of selected central nervous system (CNS) pathologies. We have paid particular attention to mouse genetic models, which in the last decade have significantly advanced our understanding of the function of IF proteins in many cell types including astroglial cells.

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Abbreviations

CNS:

central nervous system

ENU:

ethylnitrosourea

GFAP:

glial fibrillary acidic protein

IF:

intermediate filament

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Acknowledgments

The authors acknowledge research support from the Swedish Research Council (4124), the Swedish Medical Society (16850), the Arvid Carlsson Institute for Neuroscience, Swedish stroke foundation, åhlén‐stiftelsen and Torsten och Ragnar Söderbergs.

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  1. M. Pekny
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  2. U. Wilhelmsson
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Editors and Affiliations

  1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, 10962, Orangeburg, Newyork, USA

    Abel Lajtha (Director) (Director)

  2. Department of Neurology (Division of Neurochemistry and Neurobiology), University of Iowa College of Medicine and Veterans Administration Medical Center, 52242, lowa, lowa, USA

    Ramon Lim

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Pekny, M., Wilhelmsson, U. (2006). GFAP and Astrocyte Intermediate Filaments. In: Lajtha, A., Lim, R. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30381-9_14

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