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Actin, Actin-binding Proteins and Myosins in Nervous System

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Handbook of Neurochemistry and Molecular Neurobiology

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Abstract:

In this chapter, I summarize the basic properties of actin, including polymerization process, polarity of F-actin, and treadmiling, which are common in nerve cells as well as other nonmuscle and muscle cells. The properties are modulated by varieties of actin-binding proteins. Thus, I pick up some major actin-binding proteins expressing in nerve cells, and summarize (i) how these proteins affect actin properties, and (ii) possible functions of these proteins in nervous system. Finally, both conventional and unconventional myosins expressing in nerve cells are also shown, and discussed in the possible roles in actin dynamics in nerve cells.

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Abbreviations

G-actin:

globular actin

F-actin:

filamentous actin

ATP:

adenosine 5′-triphosphate

ADP:

adenosine 5′-diphosphate

Cc:

critical concentration

NMDA:

N-methyl-D-aspartate

DRG:

dorsal root ganglion

ADF:

actin depolymerizing factor

Arp:

actin related protein

LPA:

lysophosphatidic acid

GTP:

guanosine 5′-triphosphate

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Authors
  1. R. Ishikawa
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Editors and Affiliations

  1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, Newyork, 10962, USA

    Abel Lajtha (Director) (Director)

  2. Department of Neurosciences Division of Neurology, Medical University of South Carolina, 96 Jonathan Lucas Street Suite 309, Charleston, SC 29425, USA

    Naren Banik (Professor) (Professor)

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© 2007 Springer Science+Business Media, LLC

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Ishikawa, R. (2007). Actin, Actin-binding Proteins and Myosins in Nervous System. In: Lajtha, A., Banik, N. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30379-6_6

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