Synaptotagmin is an integral type I transmembrane glycoprotein that possesses two C2 calcium-binding domains. C2-domains are present in several other proteins such as the calcium-dependent isoforms of protein kinase C and phospholipase D where they are known to regulate Ca-dependent binding to phospholipid membranes. More than 10 different synaptotagmins are known, that are widely expressed in many tissues. Best characterized is synaptotagmin I, a resident of synaptic vesicles and neurosecretory granules. Synaptotagmin I probably functions as an exocytotic Ca-receptor that links the calcium signal to membrane fusion by means of Ca-dependent binding to membranes and (possibly) to SNAREs.
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© 2004 Springer-Verlag
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(2004). Synaptotagmin. In: Encyclopedic Reference of Molecular Pharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29832-0_1569
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DOI: https://doi.org/10.1007/3-540-29832-0_1569
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-42843-5
Online ISBN: 978-3-540-29832-8
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