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Rothman-Makai syndrome

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Dermatology Therapy

Part of the book series: A to Z Essentials ((ATOZ))


Lipogranulomatosis subcutanea; adipone-crosis subcutanea; lipophagic panniculitis of childhood


Panniculitis of children, characterized by subcutaneous nodules without systemic signs or symptoms


May be a variant of Weber-Christian disease; mechanism of disease unknown

Clinical manifestation

Well-demarcated, somewhat painful, symmetrical subcutaneous nodules, most often on lower extremities and trunk; atrophy in lesions of lipophagic panniculitis variant

Differential diagnosis

Thrombophlebitis; vasculitis; sarcoidosis; alpha-1 antitrypsin deficiency panniculitis; polyarteritis nodosa; eosinophilic fasciitis; eosinophilic myalgia syndrome; erythema induratum; erythema nodosum; leukemia; lipodermatosclerosis; lymphoma; pancreatic panniculitis; poststeroid panniculitis; scleroderma panniculitis; cytophagic histiocytic panniculitis; Sweet's syndrome


No therapy indicated

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  • Requena L, Sanchez Yus E (2001) Panniculitis. Part II. Mostly lobular panniculitis. Journal of the American Academy of Dermatology 45(3):325–361

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© 2004 Springer-Verlag

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(2004). Rothman-Makai syndrome. In: Levine, N., Levine, C.C. (eds) Dermatology Therapy. A to Z Essentials. Springer, Berlin, Heidelberg.

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-00864-4

  • Online ISBN: 978-3-540-29668-3

  • eBook Packages: Springer Book Archive

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