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Roseola infantum; exanthem subitum; sixth disease
Childhood exanthematous disease caused by Human Herpesvirus-6 (HHV-6)
Main cause HHV-6B; in primary infection, replication of the virus in leukocytes and salivary glands; early invasion of the central nervous system, causes seizures and other CNS complications
Most primary infections asymptomatic; typical presentation: 9–12-month-old child with abrupt onset of high fever (40°C), lasting for 3 days with nonspecific complaints; febrile seizures may occur; rapid defervescence of fever occurring with onset of pink morbilliform exanthem composed of either discrete, small, pale pink papules or a blanchable exanthem, lasting 2 days; enanthem (Nagayama's spots) with erythematous papules on the mucosa of the soft palate and base of the uvula
Other viral exanthems, including mononucleosis; rubeola and rubella; scarlet fever; meningococcemia; dengue fever; medication...