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Part of the A to Z Essentials book series (ATOZ)


Roseola infantum; exanthem subitum; sixth disease


Childhood exanthematous disease caused by Human Herpesvirus-6 (HHV-6)


Main cause HHV-6B; in primary infection, replication of the virus in leukocytes and salivary glands; early invasion of the central nervous system, causes seizures and other CNS complications

Clinical manifestation

Most primary infections asymptomatic; typical presentation: 9–12-month-old child with abrupt onset of high fever (40°C), lasting for 3 days with nonspecific complaints; febrile seizures may occur; rapid defervescence of fever occurring with onset of pink morbilliform exanthem composed of either discrete, small, pale pink papules or a blanchable exanthem, lasting 2 days; enanthem (Nagayama's spots) with erythematous papules on the mucosa of the soft palate and base of the uvula

Differential diagnosis

Other viral exanthems, including mononucleosis; rubeola and rubella; scarlet fever; meningococcemia; dengue fever; medication...

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  • Blauvelt A (2001) Skin diseases associated with human herpesvirus 6, 7, and 8 infection. Journal of Investigative Dermatology. Symposium Proceedings 6(3):197–202

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© 2004 Springer-Verlag

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(2004). Roseola. In: Levine, N., Levine, C.C. (eds) Dermatology Therapy. A to Z Essentials. Springer, Berlin, Heidelberg.

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-00864-4

  • Online ISBN: 978-3-540-29668-3

  • eBook Packages: Springer Book Archive