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Cytotoxic drugs

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Class and Category

Antineoplastic and immunosuppressive drugs, of which there are many, viz: alkylating agents, antifolates, purine antagonists, vinca alkaloids, etc.

Indications

Most were devised for treatment of neoplasms; many have been used as treatment for autoimmune diseases. 'Diseases desperate grown, by desperate appliances are reliev'd, or not at all.'

Dosage

Varies with the drug, and its indications for use, and severity of disorder for which it is used.

Contraindications

No absolute contraindications; however, active infections of many sorts are relative contraindications. Non-immune cytopenias might be contraindications.

Adverse Reactions

Vary with the drug. In general, there is dose limiting toxicity to bone marrow and intestinal mucosa. Cellular and humoral immunity are suppressed by alkylating agents; pulmonary fibrosis; cytopenias; nausea, vomiting are common to many.

Drug Interactions

Vary with individual drugs.

Mechanism of Action

In general, they disturb DNA...

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References

  • Chabner BA, Ryan DP, Paz-Ares L, Garcia-Carbonero R, Calabresi P (2001) Antineoplastic agents. In: Hardman JG, Limbird LE (eds) Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th edn. McGraw-Hill, New York, pp 1389–459

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© 2004 Springer-Verlag

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(2004). Cytotoxic drugs. In: Moreland, L.W. (eds) Rheumatology and Immunology Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29662-X_834

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  • DOI: https://doi.org/10.1007/3-540-29662-X_834

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20625-5

  • Online ISBN: 978-3-540-29662-1

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