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Cyclosporine

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Trade Names

Neoral; Sandimmune.

Class and Category

Immunosuppressive agent.

Indications

Rheumatoid arthritis. Several randomized controlled trials have demonstrated efficacy of cyclosporine in RA. The first reported success of combination therapy was achieved by adding cyclosporine to methotrexate. Patients with rheumatoid arthritis who did not respond to a maximum dose of methotrexate (15 mg/wk) were treated with the addition of cyclosporine at a mean dosage of 2.97 mg/kg of body weight per day. Clinically meaningful improvements were observed. Transient increases in serum creatinine concentration were frequently reported in patients taking cyclosporine, but these values returned to the normal range when the dose of the drug was adjusted. However, an increase in serum creatinine concentration that is sustained longer than 3 months can be associated with permanent residual loss of renal function. Daily doses of cyclosporine that exceed 4 mg/kg are associated with biopsy-proven...

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  • DOI: 10.1007/3-540-29662-X_825
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References

  • Fox R, Morgan S, Smith H, Robbins D, Meligoni S, Caldwell J, et al (1998) Treatment of RA patients with methotrexate plus cyclosporin A leads to elevation of plasma methotrexate levels and decrease of 7 hydroxymethotrexate levels. Arthritis Rheumatism 41:S138

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  • Panayi GS, Tugwell P (1993) An international consensus report. The use of cyclosporin A in rheumatoid arthritis. British Journal of Rheumatology 32(Suppl 1):1–3

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  • Tugwell P, Pincus T, Yocum D, Stein M, Gluck O, Kraag G, et al (1995) Combination therapy with cyclosporine and methotrexate in severe rheumatoid arthritis. The Methotrexate-Cyclosporine Combination Study Group. New Engl J Med 333:137–41

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  • Yocum DE, Stein M, Pincus T (1998) Long-term safety of cyclosporine/sandimmune alone and in combinations with methotrexate in the treatment of active rheumatoid arthritis: analysis of open label extension studies. Arthritis Rheumatology 41:S364

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© 2004 Springer-Verlag

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(2004). Cyclosporine. In: Moreland, L.W. (eds) Rheumatology and Immunology Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29662-X_825

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  • DOI: https://doi.org/10.1007/3-540-29662-X_825

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20625-5

  • Online ISBN: 978-3-540-29662-1

  • eBook Packages: Springer Book Archive