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Cyclooxygenase-2

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Synonyms

COX-2, endoperoxide synthase-2, prostaglandin H synthase-2.

Definition

Isozyme of cyclooxygenase that is induced by a variety of proinflammatory stimuli and growth factors; catalyzes the conversion of arachidonic acid to prostaglandin H2.

Full Text

Cyclooxygenase-2 (COX-2) produces prostaglandin H2 at sites of inflammation and in the kidney and central nervous system. The primary role of COX-2 is to produce pro-inflammatory prostaglandins, regulate renal blood flow, and regulate temperature and pain sensation in the central nervous system. COX-2 is induced in leukocytes, fibroblasts, endothelial cells and neurons by stimuli such as cytokines, cell growth factors, and endotoxin. COX-2 is inhibited by both non-selective non-steroidal antiinflammatory drugs (ibuprofen and aspirin) and selective COX-2 inhibitors (rofecoxib).

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References

  • Penrose JF, Austen KF (2001) Arachidonic acid pathways. In: Austen KF, Frank MM, Atkinson JP, Cantor H (eds) Samter's Immunologic Diseases. Lippincott Williams & Wilkins, Philadelphia, 299–316

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© 2004 Springer-Verlag

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(2004). Cyclooxygenase-2. In: Moreland, L.W. (eds) Rheumatology and Immunology Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29662-X_822

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  • DOI: https://doi.org/10.1007/3-540-29662-X_822

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20625-5

  • Online ISBN: 978-3-540-29662-1

  • eBook Packages: Springer Book Archive