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Cyclooxygenase-1

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Synonyms

COX-1, endoperoxide synthase-1, prostaglandin H synthase-1.

Definition

Constitutively expressed isozyme of cyclooxygenase that catalyzes the conversion of arachidonic acid to prostaglandin H2.

Full Text

Cyclooxygenase-1 (COX-1) is a constitutively expressed isozyme of cyclooxygenase that produces prostaglandins important in homeostatic functions of virtually all cells. Among the functions of prostaglandins produced by COX-1 are: maintenance of gastric mucosa, regulation of sleep cycles, control of vascular tone, and control of platelet function. Cyclooxygenase-1 is inhibited by the non-selective non-steroidal antiinflammatory drugs (e.g. ibuprofen, but not rofecoxib).

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References

  • Penrose JF, Austen KF (2001) Arachidonic acid pathways. In: Austen KF, Frank MM, Atkinson JP, Cantor H (eds) Samter's Immunologic Diseases. Lippincott Williams & Wilkins, Philadelphia, pp 299–316

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© 2004 Springer-Verlag

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(2004). Cyclooxygenase-1. In: Moreland, L.W. (eds) Rheumatology and Immunology Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29662-X_821

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  • DOI: https://doi.org/10.1007/3-540-29662-X_821

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20625-5

  • Online ISBN: 978-3-540-29662-1

  • eBook Packages: Springer Book Archive