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Anti-La (SS-B) antibodies

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Rheumatology and Immunology Therapy
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Definition

Autoantibodies directed against the La (SS-B) protein, a nuclear 47kD phosphoprotein.

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Anti-La antibodies, also termed anti-SS-B antibodies, are autoantibodies against a nuclear 47kD phosphoprotein that associates with several small RNAs synthesized by RNA polymerase III. The La (SS-B) protein is a transcription-termination factor for RNA polymerase III. Anti-La (SS-B) antibodies are detectable by immunoprecipitation, double immunodiffusion (Ouchterlony), counterimmunoelectrophoresis, immunoblotting, and ezyme-linked immunosorbent assays (ELISAs) using recombinant La protein.

Anti-La, or SS-B, autoantibodies occur in 10–20% of unselected patients with systemic lupus erythematosus and approximately 50% of patients with primary or secondary Sjögren's syndrome. Maternal anti-La (SS-B) autoantibodies are associated with neonatal lupus syndromes, particularly congenital heart block. Anti-La (SS-B) antibodies commonly occur in association with autoantibodies to Ro (SS-A).

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References

  • Buyon JP (1998) Neonatal lupus and autoantibodies reactive with SSA/Ro-SSB/La. Scand J Rheumatol 107:23–30

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  • Reeves WH, Satoh M (2001) Autoantibodies in systemic lupus erythematosus. In: Koopman WJ (ed) Arthritis and Allied Conditions. Lippincott Williams & Wilkins, Philadelphia, pp 1480–502

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© 2004 Springer-Verlag

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(2004). Anti-La (SS-B) antibodies. In: Moreland, L.W. (eds) Rheumatology and Immunology Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29662-X_239

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  • DOI: https://doi.org/10.1007/3-540-29662-X_239

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20625-5

  • Online ISBN: 978-3-540-29662-1

  • eBook Packages: Springer Book Archive

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