Trade Names
Alocril; Tilade.
Class and Category
Mast cell stabilizer.
Indications
Maintenance therapy for patients with mild to moderate asthma.
Dosage
Inhalation aerosol used 2–4 times per day at a dose of 2–4 inhalations per use. Duration of effect approximately 2 hours.
Contraindications
Use in children under 6 years old not well studied. Ineffective as a rescue therapy for acute exacerbation of asthma.
Adverse Reactions
Generally well tolerated. Sometimes associated with an unpleasant taste or minor throat irritation or cough.
Drug Interactions
None known.
Mechanism of Action
Inhibits release of proinflammatory mediators including histamine, leukotrienes, and slow reacting substance of anaphylaxis (SRSA) from a variety of inflammatory cell types including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets.
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References
Lexicomp 2003
The Childhood Asthma Management Program Research Group (2000) Long-term effects of budesonide or nedocromil in children with asthma. New Engl J Med 343(15):1054–63
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© 2004 Springer-Verlag
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(2004). Nedocromil. In: Moreland, L.W. (eds) Rheumatology and Immunology Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29662-X_1955
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DOI: https://doi.org/10.1007/3-540-29662-X_1955
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20625-5
Online ISBN: 978-3-540-29662-1
eBook Packages: Springer Book Archive