Naproxen

Reference work entry
DOI: https://doi.org/10.1007/3-540-29662-X_1947

Synonyms

Naproxen sodium.

Trade Names

Aleve, Anaprox, Naprelen, Naprosyn, numerous others.

Class and Category

Non-steroidal antiinflammatory drug; non-selective cyclooxygenase inhibitor.

Indications

Ankylosing spondylitis, arthralgia, bursitis, dental pain, dysmenorrhea, fever, gout arthritis, headache, juvenile rheumatoid arthritis, mild-moderate pain, myalgia, osteoarthritis, rheumatoid arthritis, tendonitis.

Dosage

Adults: 440–1000 mg per day divided twice daily. Children: 10–15 mg/kg/day.

Contraindications

Non-steroidal antiinflammatory drug hypersensitivity, salicylate hypersensitivity.

Adverse Reactions

Gastrointestinal: gastroduodenal ulcer, lower gastrointestinal tract ulcer or stricture, hepatic toxicity (elevated liver enzymes, hepatic failure).

Renal: peripheral edema, acute reduction in renal function, hyperkalemia, interstitial nephritis with nephrotic syndrome, renal papillary necrosis, analgesic nephropathy.

Cardiovascular: exacerbation of hypertension, exacerbation of...

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References

  1. Bethesda, MD (2001) American Society of Hospital Pharmacists. AHFS drug information. Board of Directors of the American Society of Hospital Pharmacists, 2001Google Scholar
  2. Roberts LJ 2nd, Morrow JD (2001) Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout. In: Hardman JG, Limbird LE (eds) Pharmacological Basis of Therapeutics, 9th ed. McGraw-Hill, New York, 687–731Google Scholar

Copyright information

© Springer-Verlag 2004