Reference work entry


Naproxen sodium.

Trade Names

Aleve, Anaprox, Naprelen, Naprosyn, numerous others.

Class and Category

Non-steroidal antiinflammatory drug; non-selective cyclooxygenase inhibitor.


Ankylosing spondylitis, arthralgia, bursitis, dental pain, dysmenorrhea, fever, gout arthritis, headache, juvenile rheumatoid arthritis, mild-moderate pain, myalgia, osteoarthritis, rheumatoid arthritis, tendonitis.


Adults: 440–1000 mg per day divided twice daily. Children: 10–15 mg/kg/day.


Non-steroidal antiinflammatory drug hypersensitivity, salicylate hypersensitivity.

Adverse Reactions

Gastrointestinal: gastroduodenal ulcer, lower gastrointestinal tract ulcer or stricture, hepatic toxicity (elevated liver enzymes, hepatic failure).

Renal: peripheral edema, acute reduction in renal function, hyperkalemia, interstitial nephritis with nephrotic syndrome, renal papillary necrosis, analgesic nephropathy.

Cardiovascular: exacerbation of hypertension, exacerbation of...

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  1. Bethesda, MD (2001) American Society of Hospital Pharmacists. AHFS drug information. Board of Directors of the American Society of Hospital Pharmacists, 2001Google Scholar
  2. Roberts LJ 2nd, Morrow JD (2001) Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout. In: Hardman JG, Limbird LE (eds) Pharmacological Basis of Therapeutics, 9th ed. McGraw-Hill, New York, 687–731Google Scholar

Copyright information

© Springer-Verlag 2004