Myositis ossificans progressiva
Autosomal dominant disorder, clinically different from simple myositis ossificans. Muscles usually become warm and tender to the touch beginning in childhood. These lesions often shrink and get hard with recurrent disappearance and recurrence. Muscles most involved include those of the spine, abdominal wall, chest and extremities. Microdactyly of the first toe, and thumb, exostosis, hypogenitalism, ear lobule absence and deafness may all occur.
Some patients respond to ethane-1-hydroxy-1,1-diphosphonate therapy.
- Ruddy S, et al (eds) (2001) Kelley's Text book of Rheumatology 6th ed. WB Saunders, PhiladelphiaGoogle Scholar