Ibuprofen

Reference work entry
DOI: https://doi.org/10.1007/3-540-29662-X_1319

Trade Names

Motrin; Advil; numerous other combination formulations.

Class and Category

Non-steroidal antiinflammatory drug; non-selective cyclooxygenase inhibitor.

Indications

Arthralgia, dental pain, dysmenorrhea, fever, headache, juvenile rheumatoid arthritis, migraine, mild-moderate pain, myalgia, osteoarthritis, rheumatoid arthritis.

Dosage

Adults: 400–800 mg tid-qid; Children: 5–10 mg/kg.

Contraindications

Non-steroidal antiinflammatory drug hypersensitivity, salicylate hypersensitivity.

Adverse Reactions

Gastrointestinal: gastroduodenal ulcer, lower gastrointestinal tract ulcer or stricture, hepatic toxicity (elevated liver enzymes, hepatic failure).

Renal: peripheral edema, acute reduction in renal function, hyperkalemia, interstitial nephritis with nephrotic syndrome, renal papillary necrosis, analgesic nephropathy.

Cardiovascular: exacerbation of hypertension, exacerbation of congestive heart failure.

Allergic, pseudoallergic and immunologic: NSAID-induced rhinitis and asthma,...

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References

  1. Bethesda MD (2001) American Society of Hospital Pharmacists. AHFS drug information. Board of Directors of the American Society of Hospital Pharmacists,Google Scholar
  2. Roberts LJ 2nd, Morrow JD (2001) Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout. In: Hardman JG, Limbird LE (eds) Pharmacological Basis of Therapeutics, 9th ed. McGraw-Hill, New York, pp 687–731Google Scholar

Copyright information

© Springer-Verlag 2004