Reference work entry
DOI: https://doi.org/10.1007/3-540-29662-X_1319

Trade Names

Motrin; Advil; numerous other combination formulations.

Class and Category

Non-steroidal antiinflammatory drug; non-selective cyclooxygenase inhibitor.


Arthralgia, dental pain, dysmenorrhea, fever, headache, juvenile rheumatoid arthritis, migraine, mild-moderate pain, myalgia, osteoarthritis, rheumatoid arthritis.


Adults: 400–800 mg tid-qid; Children: 5–10 mg/kg.


Non-steroidal antiinflammatory drug hypersensitivity, salicylate hypersensitivity.

Adverse Reactions

Gastrointestinal: gastroduodenal ulcer, lower gastrointestinal tract ulcer or stricture, hepatic toxicity (elevated liver enzymes, hepatic failure).

Renal: peripheral edema, acute reduction in renal function, hyperkalemia, interstitial nephritis with nephrotic syndrome, renal papillary necrosis, analgesic nephropathy.

Cardiovascular: exacerbation of hypertension, exacerbation of congestive heart failure.

Allergic, pseudoallergic and immunologic: NSAID-induced rhinitis and asthma,...

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  1. Bethesda MD (2001) American Society of Hospital Pharmacists. AHFS drug information. Board of Directors of the American Society of Hospital Pharmacists,Google Scholar
  2. Roberts LJ 2nd, Morrow JD (2001) Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout. In: Hardman JG, Limbird LE (eds) Pharmacological Basis of Therapeutics, 9th ed. McGraw-Hill, New York, pp 687–731Google Scholar

Copyright information

© Springer-Verlag 2004