Ibuprofen

Trade Names

Motrin; Advil; numerous other combination formulations.

Class and Category

Non-steroidal antiinflammatory drug; non-selective cyclooxygenase inhibitor.

Indications

Arthralgia, dental pain, dysmenorrhea, fever, headache, juvenile rheumatoid arthritis, migraine, mild-moderate pain, myalgia, osteoarthritis, rheumatoid arthritis.

Dosage

Adults: 400–800 mg tid-qid; Children: 5–10 mg/kg.

Contraindications

Non-steroidal antiinflammatory drug hypersensitivity, salicylate hypersensitivity.

Adverse Reactions

Gastrointestinal: gastroduodenal ulcer, lower gastrointestinal tract ulcer or stricture, hepatic toxicity (elevated liver enzymes, hepatic failure).

Renal: peripheral edema, acute reduction in renal function, hyperkalemia, interstitial nephritis with nephrotic syndrome, renal papillary necrosis, analgesic nephropathy.

Cardiovascular: exacerbation of hypertension, exacerbation of congestive heart failure.

Allergic, pseudoallergic and immunologic: NSAID-induced rhinitis and asthma,...