Reference work entry
DOI: https://doi.org/10.1007/3-540-29662-X_1308


Agammaglobulinemia, humoral immunodeficiency.


Hypogammaglobulinemia (usually less than 200–250 mg/dl of IgG) results from lack of production; excessive loss of immunoglobulins; or both. It is conventionally divided into acquired and primary types. In adults the most common of the primary types is common variable immunodeficiency, the precise cause of which has not been determined, but the basis appears to be a defective gene in the class III region of the MHC. In this disorder, there is usually a deficiency in both IgG and IgA. Other primary types include severe combined immunodeficiency, adenosine deaminase deficiency, and the X-linked immunodeficiency diseases. (See definitions for these). Acquired hypogammaglobulinemia is more common than primary deficiency disorders, and malnutrition is probably the most common worldwide cause of acquired disease. Other causes for acquired hypogammaglobulinemia include neoplasms such as multiple myeloma, chronic lymphocytic...

This is a preview of subscription content, log in to check access.


  1. Janeway CA, Travers P, Walport M, Shlomchik M (2001) Immunobiology (Failures of host defense mechanisms). Garland Publishing, New York, pp 425–69Google Scholar
  2. Kreth HW (1990) Acquired immunodeficiency. Fortschr Med 108:511–3PubMedGoogle Scholar
  3. Akman S, Guven AG, Ince S, Yegin O (2002) IgG and IgG subclasses deficiency in children underoing continuous ambulatory peritoneal dialysis and its provocative factors. Pediatr Int 44:511–3CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2004