Elevated serum levels of immunoglobulin and pronounced antibody responses may be seen with infection and inflammation. This is thought to be an effect of B cell activation producing antibodies that are not associated with the accompanying infection or disease. Infections often associated with hypergammaglobulinemia include the acquired immunodefiency syndrome (AIDS), endocarditis, mononucleosis, syphilis, and parasitic infection. Disease states associated with hypergammaglobulinemia include chronic diseases, including systemic lupus erythematosis (SLE), cystic fibrosis, and rheumatoid arthritis. Polyclonal gammopathies related to an infection are usually not involved in the disease process itself, and is not pathologic.
The mechanism of hypergammaglobulinemia in patients with Human immunodeficiency virus (HIV) is thought to be caused by CD70 expression, which stimulates memory B cell production and differentiation into plasma cells, which then results in elevated serum...
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