Hypergammaglobulinemia

Reference work entry
DOI: https://doi.org/10.1007/3-540-29662-X_1285

Definition

Elevated serum levels of immunoglobulin and pronounced antibody responses may be seen with infection and inflammation. This is thought to be an effect of B cell activation producing antibodies that are not associated with the accompanying infection or disease. Infections often associated with hypergammaglobulinemia include the acquired immunodefiency syndrome (AIDS), endocarditis, mononucleosis, syphilis, and parasitic infection. Disease states associated with hypergammaglobulinemia include chronic diseases, including systemic lupus erythematosis (SLE), cystic fibrosis, and rheumatoid arthritis. Polyclonal gammopathies related to an infection are usually not involved in the disease process itself, and is not pathologic.

The mechanism of hypergammaglobulinemia in patients with Human immunodeficiency virus (HIV) is thought to be caused by CD70 expression, which stimulates memory B cell production and differentiation into plasma cells, which then results in elevated serum...

This is a preview of subscription content, log in to check access.

References

  1. Heinzel FP (2000) Antibodies. In: Mandell GL, et al (eds) Principles and Practice of Infectious Diseases, 5th ed. Churchill Livingstone, St. LouisGoogle Scholar
  2. Nagase H, Agematsu K, Kitano K, Takamoto M, Okubo Y, Komiyama A, Sugane K (2001) Mechanism of hypergammaglobulinemia by HIV infection: circulating memory B-cell reduction with plasmacytosis. Clin Immunol 100(2):250–9PubMedCrossRefGoogle Scholar
  3. Notermans DW, de Jong JJ, Goudsmit J, et al (2001) Potent antiretroviral therapy initiates normalization of hypergammaglobulinemia and a decline in HIV type 1-specific antibody responses. AIDS Res Hum Retroviruses 17(11):1003–8PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2004