Definition
When a ligand or a substrate comes into contact with the binding site of a protein or the enzyme's active site, the active site slightly changes or moulds itself around the substrate/ligand for an effective fit. In some cases only few atoms move, sometimes whole secondary structures move, leading to conformational changes of the protein. In other cases the quaternary structure is changed. The conformational changes are often used to transport information. Other synonymous terms for induced fit are structural plasticity and conformational changes.
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© 2006 Springer-Verlag
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(2006). Induced Fit. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-29623-9_7489
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DOI: https://doi.org/10.1007/3-540-29623-9_7489
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-44244-8
Online ISBN: 978-3-540-29623-2
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