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Functional Genomics, the Systematic Analysis of the Function of All Genes and Gene Products in Parallel

  • Reference work entry
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine

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Definition

Functional genomics is the systematic study of gene products and their functions in biological processes. Functional genomics deals with gene knockouts and their phenotypic characterization, gene expression profiles (mRNA or protein levels) in different tissues of an organism, the sub‐cellular location of proteins, three‐dimensional protein structure, post‐translational modification and processing of proteins, protein‐protein interactions, and many more functional aspects of gene products that can be assayed systematically and at high throughput.

Structural Genomics: Structure‐to‐Function Approaches

Introduction

In a sense, life can be considered a ‘computational’ process: The organism ‘computes’ its phenotype from the information in its genome, modulated by the environment as well as by some random components. This ‘computation’ is carried out by a complex network of processes, involving many of the genes and gene products of the organism. These networks have evolved over...

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Acknowledgements

The concepts expressed in this review have been the result of many discussions with many people. I would particularly like to thank Bernhard Herrmann, Marie‐Laure Yaspo, Steffen Hennig, Patricia Ruiz, Claudia Falter, Ralf Herwig, Heinz Himmelbauer, Marc Sultan, Zoltan Konthur, Dominique Vanhecke, Michal Janitz, Ilaria Piccini, Sylvia Krobitsch, Günther Zehetner, Andreas Hewelt and Christoph Wierling for contributions and discussion.

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  1. Max Planck Institute for Molecular Genetics, Berlin, Germany

    H. Lehrach

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  1. H. Lehrach
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Correspondence to H. Lehrach .

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© 2005 Springer-Verlag

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Lehrach, H. (2005). Functional Genomics, the Systematic Analysis of the Function of All Genes and Gene Products in Parallel. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-29623-9_5184

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