Definition
The history of life as far as we know at present spans the enormous time period of around 3.5 billion years. The ‘tree of life’ concept originally starting with Darwin's pioneering ideas was for more than a century mainly based on findings from the fossil record and morphological comparison of living species. With the availability of the DNA sequences of several complete genomes and the sequences of genes and their products (proteins), we now enter an era where the ‘tree of life’, which shows the main phyla as they arose from their respective ancestors, can be inspected directly by genome comparison between species.
Practical applications of sequence annotation in the context of evolution are, e.g. the development of the major histocompatibility complex (MHC) between primates (1) or over long time scales (2) or studies on the origin of vertebrates (3).
Characteristics
The main difference between ‘classical’ sequence annotation and annotation with an evolutionary focus is the...
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References
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© 2006 Springer-Verlag
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Hennig, S. (2006). Sequence Annotation in Evolution. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-29623-9_2050
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DOI: https://doi.org/10.1007/3-540-29623-9_2050
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-44244-8
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