Drug-Induced Hypersensitivity syndrome (DIHS)

Reference work entry
DOI: https://doi.org/10.1007/3-540-27806-0_406

Drug-induced hypersensitivity syndrome (DIHS) is a potentially fatal drug eruption, usually accompanied by abnormalities of multiple organ systems (e.g hepatitis and nephritis). This syndrome typically develops 3 weeks to 6 months after starting treatment with anticonvulsants, beginning with a fever which is shortly followed by a generalized maculopapular eruption and variable degrees of lymphadenopathy. Withdrawal of the causative drug is often followed by exacerbations, rather than rapid clearing of the reaction. Reactivation of human herpesvirus 6 has been implicated in the pathogenesis.

 Drugs, Allergy to

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© Springer-Verlag 2005