Drug-Induced Hypersensitivity syndrome (DIHS)
Drug-induced hypersensitivity syndrome (DIHS) is a potentially fatal drug eruption, usually accompanied by abnormalities of multiple organ systems (e.g hepatitis and nephritis). This syndrome typically develops 3 weeks to 6 months after starting treatment with anticonvulsants, beginning with a fever which is shortly followed by a generalized maculopapular eruption and variable degrees of lymphadenopathy. Withdrawal of the causative drug is often followed by exacerbations, rather than rapid clearing of the reaction. Reactivation of human herpesvirus 6 has been implicated in the pathogenesis.