Chemotaxis of Neutrophils

  • Lasse Leino
Reference work entry
DOI: https://doi.org/10.1007/3-540-27806-0_251

Synonyms

Migration of neutrophils

Definition

Chemotaxis is the reaction by which the direction of neutrophil locomotion is determined by chemical substances in the environment of the cell. This is distinct from chemokinesis where the speed, or frequency, of locomotion is determined by chemical substances while lacking a directional component. Typically, a chemical substance, often called a chemoattractant in this connection, determines both cell speed and direction; thus a neutrophil moving directionally and also accelerating is showing both chemotaxis and chemokinesis. Transmigration is a special form of chemotaxis which defines neutrophil locomotion through a cell barrier, e.g. endothelial cell monolayer, along an increasing concentration of chemoattractant.

Characteristics

Neutrophils are the first cells of the body's defence system to be recruited at sites of inflammation and infection. The circulating neutrophils are selectively accumulated into inflamed tissues by proinflammatory...

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References

  1. 1.
    Cicchetti G, Allen PG, Glogauer M (2002) Chemotactic signaling pathways in neutrophils: from receptor to actin assembly. Crit Rev Oral Biol Med 13:220–228PubMedCrossRefGoogle Scholar
  2. 2.
    Worthylake RA, Burridge K (2001) Leukocyte transendothelial migration: orchestrating the underlying molecular machinery. Curr Opin Cell Biol 13:569–577PubMedCrossRefGoogle Scholar
  3. 3.
    Wilkinson PC (1998) Assays of leukocyte locomotion and chemotaxis. J Immunol Methods 216 (1–2):139–153PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Lasse Leino
    • 1
  1. 1.Department of Clinical ChemistryUniversity of TurkuTurkuFinland