Chemotaxis of Neutrophils
Migration of neutrophils
Chemotaxis is the reaction by which the direction of neutrophil locomotion is determined by chemical substances in the environment of the cell. This is distinct from chemokinesis where the speed, or frequency, of locomotion is determined by chemical substances while lacking a directional component. Typically, a chemical substance, often called a chemoattractant in this connection, determines both cell speed and direction; thus a neutrophil moving directionally and also accelerating is showing both chemotaxis and chemokinesis. Transmigration is a special form of chemotaxis which defines neutrophil locomotion through a cell barrier, e.g. endothelial cell monolayer, along an increasing concentration of chemoattractant.
Neutrophils are the first cells of the body's defence system to be recruited at sites of inflammation and infection. The circulating neutrophils are selectively accumulated into inflamed tissues by proinflammatory...