Chemotactic cytokines, small secreted cytokines.
Family of small cytokines with chemotactic properties that signal through seven transmembrane receptors coupled to GI proteins. Besides regulating leukocyte recruitment and migration, chemokines have many other physiologic functions, including angiogenesis/angiostasis, lymphocyte development, immunoregulation, and metastasis (1–3).
Although the first chemokines were originally identified and characterized based on their biological activity, many members of this family have been recently identified through the application of bioinformatics and expressed sequence tag (EST) databases (2).
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