Reference work entry

A homodimeric molecule present on T cells. It acts as a receptor for CD80 and CD86 molecules. Cross-linking of CD28 with anti-CD28 antibody restores proliferation in the presence of suboptimal concentrations of anti-CD3, while ligation of CD28 with its natural ligands costimulates T cell effector and helper functions.

 Lymphocyte Proliferation

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© Springer-Verlag 2005