Carboxylic acid amides do not generally belong to the substances with antimicrobial effect. Toxophoric groups or toxophoric structural elements have to be introduced to obtain antimicrobially active aliphatic carboxylic acid amides. This possibility is exemplified by amides which in 2-position to the electronegative carboxylamide grouping possess a halogen atom, thus ranking among the electrophilic active microbicides which are described under ‘17. Compounds with Activated Halogen Atoms’. The addition of formaldehyde (2.1.) to such halogenated amides leads to antimicrobially effective N-hydroxymethyl amides, whose special feature is the presence of two toxophoric groups: an activated halogen atom and an activated hydroxymethyl group. Being formaldehyde releasing compounds, they are treated under ‘3.4. Amide-Formaldehyde-Reaction-Products’, as well as N-hydroxymethyl diamides of carbonic acid = N-hydroxymethyl ureas (3.4.3.).
Salicylanilides (2-hydroxybenzanilides), long chain...
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© 2004 Kluwer Academic Publishers
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Paulus, W. (2004). Amides. In: Paulus, W. (eds) Directory of Microbicides for the Protection of Materials. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2818-0_33
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DOI: https://doi.org/10.1007/1-4020-2818-0_33
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Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-2817-5
Online ISBN: 978-1-4020-2818-2
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