Encyclopedia of Nanotechnology

2016 Edition
| Editors: Bharat Bhushan

Magnetic Nanoparticles for Biomedical Applications

  • Kerstin Witte
  • Cordula Grüttner
  • Wiktor Bodnar
  • Eberhard Burkel
Reference work entry
First Online:
DOI: https://doi.org/10.1007/978-94-017-9780-1_100952
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Synonyms

 Biomedical applications;  Contrast enhancement;  Drug targeting;  Hyperthermia treatment;  Magnetic nanoparticles;  Magnetic particle imaging;  Magnetic resonance imaging;  Magnetic separation;  Superparamagnetism

Definition

The physical and also chemical properties of ferri- or ferromagnetic particles in the size regime of 10–1000 nm [1] vary drastically from typical bulk materials which makes them interesting for biomedical applications. In the following, a basic overview of main synthesis routes, physical properties, as well as main uses and applications in biomedicine of magnetic nanoparticles is given.

Introduction

Magnetic nanoparticles offer attractive possibilities for application in biomedicine. Living cells are in a size regime of 10 μm. Magnetic nanoparticles are smaller by three orders of magnitude, and their size is comparable to the size of viruses, proteins, or genes, which means that they are “close to” the entity of interest [1]. When the particles are...

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References

  1. 1.
    Gubin, S.P. (ed.): Magnetic Nanoparticles. Wiley-VCH Weinheim, Weinheim (2009)Google Scholar
  2. 2.
    Reddy, L.H., Arias, J.L., Nicolas, J., Couvreur, P.: Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications. Chem. Rev. 112, 5818–5878 (2012)CrossRefGoogle Scholar
  3. 3.
    Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Elst, L.V., Muller, R.N.: Magnetic iron oxide nanoparticles: synthesis, stabilization, vetorization, physicochemical characterizations, and biological applications. Chem. Rev. 108, 20064–2110 (2008)CrossRefGoogle Scholar
  4. 4.
    Cox P.A.: Transition metal oxides: An introduction to their electronic structure and properties. In: Rowlinson J.S., Halpern J., Green M.L.H., Mukaiyama T. (eds.) Oxford University Press, New York, USA, preprint 2010. (1992)Google Scholar
  5. 5.
    Safarik, I., Horska, K., Safarikova, M.: Magnetic nanoparticles for biomedicine. In: Intracellular Delivery, pp. 363–372. Springer, Netherlands (2011)CrossRefGoogle Scholar
  6. 6.
    Colombo, M., Carregal-Romero, S., Casula, M.F., Gutierrez, L., Morales, M.P., Böhm, I.B., Heverhagen, J.T., Prosperi, D., Parak, W.J.: Biological applications of magnetic nanoparticles. Chem. Soc. Rev. 41, 4306–4334 (2012)CrossRefGoogle Scholar
  7. 7.
    Skomski, R.: Simple Models of Magnetism. Oxford University Press, New York, USA (2008)CrossRefGoogle Scholar
  8. 8.
    Astalan, A.P., Ahrentorp, F., Johansson, C., Larsson, K., Krozer, A.: Biomolecular reactions studied using changes in Brownian rotation dynamics of magnetic particles. Biosens. Bioelectron. 19, 945–951 (2004)CrossRefGoogle Scholar
  9. 9.
    Ito, A., Shinkai, M., Honda, H., Kobayashi, T.: Medical application of functionalized magnetic nanoparticles. J. Biosci. Bioeng. 100, 1–11 (2005)CrossRefGoogle Scholar
  10. 10.
    Pankhurst, Q., Conolly, J., Jones, S.K., Dobson, J.: Application of magnetic nanoparticles in biomedicine. J. Phys. D Appl. Phys. 36, R167–R181 (2003)CrossRefGoogle Scholar
  11. 11.
    Berry, C.C.: Progress in functionalization of magnetic nanoparticles for applications in biomedicine. J. Phys. D Appl. Phys. 42, 224003 (2009) (9pp)CrossRefGoogle Scholar
  12. 12.
    Geraldes, C.F., Laurent, S.: Classification and basic properties of contrast agents for magnetic resonance imaging. Contrast Media Mol. Imaging 4, 1–23 (2009)CrossRefGoogle Scholar
  13. 13.
    Gleich, B., Weizenecker, R.: Tomographic imaging using nonlinear response of magnetic nanoparticles. Nature 435, 1214–1217 (2005)CrossRefGoogle Scholar
  14. 14.
    Pankhurst, Q.A., Thanh, N.K.T., Jones, S.K., Dobson, J.: Progress in applications of magnetic nanoparticles in biomedicine. J. Phys. D Appl. Phys. 42, 224001 (2009) (15pp)CrossRefGoogle Scholar
  15. 15.
    Buzug, T.M., Borgert, J. (eds.): Magnetic Particle Imaging: A Novel SPIO Nanoparticle Imaging Technique, 1st edn. Springer, Heidelberg/Berlin (2012)Google Scholar
  16. 16.
    Gilchrist, R.K., Medal, R., Shorey, W.D., Hanselman, R.C., Parrott, J.C., Taylor, C.B.: Selective inductive heating of lymph nodes. Ann. Surg. 146, 596–606 (1957)CrossRefGoogle Scholar
  17. 17.
    Laurent, S., Dutz, S., Häfeli, U.O., Mahmoudi, M.: Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles. Adv. Colloid Interface Sci. 166, 8–23 (2011)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Kerstin Witte
    • 1
    • 2
  • Cordula Grüttner
    • 1
  • Wiktor Bodnar
    • 1
  • Eberhard Burkel
    • 1
  1. 1.Institute of PhysicsUniversity of RostockRostockGermany
  2. 2.Micromod Partikeltechnologie GmbHRostockGermany