The extraction efficiency of the analyte relies on the solubility of the analyte, during the liquid-liquid extraction. In a simple liquid-liquid extraction system, the partition coefficient is equal to the distribution ratio. Therefore, the distribution of the analyte between two phases does not depend on the composition of the two phases. In this situation, changes in pH of one phase do not affect the extraction the analyte. However, when the analyte undergoes an additional reaction within a phase, the distribution ratio may differ to the partition coefficient. If some ionic species are not soluble in the extract, higher extraction efficiency can be achieved by changing the pH of the raffinate. By changing the pH of the extraction system, the distribution coefficient of the solute can be changed to favor partitioning into the extract. The advantage of changing the pH of a liquid-liquid extraction system is that other functional groups are not affected by the changes in pH, so the...
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Rupasinghe, T. (2016). Liquid Extraction: Acidic Extraction. In: Wenk, M. (eds) Encyclopedia of Lipidomics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7864-1_93-1
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DOI: https://doi.org/10.1007/978-94-007-7864-1_93-1
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