Living Reference Work Entry

Biomarkers in Bone Disease

Part of the series Biomarkers in Disease: Methods, Discoveries and Applications pp 1-25

Date: Latest Version

Traditional Medicine and Use of Bone Biomarkers

  • Bachir BenarbaAffiliated withLaboratory Research on Biological Systems and Geomatics, Faculty of Nature and Life, University of Mascara Email author 


Traditional medicine gathers the knowledge, skills, and practices accumulated through years and transmitted generation to generation, aiming to maintain health and to treat illnesses. Although this folk medicine includes different techniques and practices, herbal medicine remains the most used by local populations in different parts of the world. In recent years, bone diseases and disorders become a major health problem. Although conventional drugs are effective, more and more studies are interested in herbal therapies. An increasing number of studies have shown promising antiosteoporotic activities of medicinal plants. Bone markers, considered as inexpensive and noninvasive tools, are used to manage the response to the herbal treatments both in vitro and in vivo. Bone turnover markers include formation markers (osteocalcin, alkaline phosphatase, osteoprotegerin, etc.) and resorption markers (CTX, NTX, Pyridinoline, Deoxypyridinoline, etc.). Clinical studies using bone markers demonstrated a preventive effect of different medicinal plants such as Aristolochia longa L., Prunus domestica L., or Citrus unshiu Marcow. regarding bone loss in menopausal women. This chapter focuses on herbal medicine and use of bone biomarkers.


Traditional medicine Medicinal plants Bone Osteoporosis Markers