Antimicrobial, Insecticides, Analgesics, and Hyaluronidases from the Venom Glands of Brachypelma Spiders

  • Herlinda Clement
  • Guillermo Barraza
  • Estefania Herrera
  • Francia García
  • Elia Diego-García
  • Elba Villegas
  • Gerardo Corzo
Living reference work entry
Part of the Toxinology book series (TOXI)


Mexico is a rich country in biological diversity; among them, the mygalomorph (also called the orthognatha) spider species of the genus Brachypelma contain in their poisonous glands a great variety of biomolecules that can have benefits in agriculture and medicine. Species of this genus have been studied at the Institute of Biotechnology (IBt-UNAM) and the Biotechnology Research Center (CeiB-UAEM) in Cuernavaca, Morelos, in order to detect venom components with biotechnological applications. This chapter addresses the advances of research on the venom components from species of the genus BrachypelmaB. smithi, B. albiceps, B. verdezi and B. vagans – which were chromatographically separated and biochemically analyzed, searching for antimicrobial, insecticidal, analgesic, and enzymatic activities. Although Brachypelma venoms contain similar types of molecules, their minor differences could be important for a gain in stability and function. The primary structures of the most relevant molecules found in those four species of Brachypelma are described and reported.


Acyl-polyamines Peptides Enzymes Analgesic Insecticidal 


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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Herlinda Clement
    • 1
  • Guillermo Barraza
    • 1
  • Estefania Herrera
    • 1
  • Francia García
    • 1
  • Elia Diego-García
    • 1
    • 2
  • Elba Villegas
    • 3
  • Gerardo Corzo
    • 1
  1. 1.Departamento de Medicina Molecular y BioprocesosInstituto de Biotecnología, UNAMCuernavacaMéxico
  2. 2.Laboratory of ToxicologyUniversity of Leuven (KUL)LeuvenBelgium
  3. 3.Laboratorio de Estructura-Función e Ingeniería de Proteínas, Centro de Investigación en BiotecnologíaUniversidad Autónoma del Estado de MorelosCuernavacaMéxico

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