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Spider Venoms pp 333-344 | Cite as

Recent Insights in Latrodectus (“Black Widow” Spider) Envenomation: Toxins and Their Mechanisms of Action

  • Osmindo Rodrigues PiresJrEmail author
  • Wagner Fontes
  • Mariana S. CastroEmail author
Reference work entry
Part of the Toxinology book series (TOXI)

Abstract

The Latrodectus genus (Araneae: Theridiidae) includes species commonly named black widow spiders. Due to highly potent neurotoxins present in Latrodectus venom, these spiders have medical interest. Envenomation is called Latrodectism and the symptoms include diaphoresis, hypertension, muscle cramping, weakness, and severe abdominal and/or back pain; however, cases of death are rare. The Latrodectus venom contains a cocktail of neurotoxic proteins collectively named latrotoxins (LTX). α-LTX strongly binds to a specific presynaptic receptor creating ionic pores, thus provoking a massive release of neurotransmitters. It displays no selectivity for specific synapse types and has no effect on non-neuronal cell types. Studies of Latrodectus venom, concerning toxin isolation, are mainly restricted to few species, although some molecular biology approaches reveal new putative latrotoxins in other Theridiidae species. This chapter offers a brief historical review and the current knowledge on Latrodectus venom and toxins.

Keywords

Latrodectus Latrodectism Latrotoxins Neurotransmitter release 

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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  1. 1.Laboratory of Toxinology, Department of Physiological Sciences/IBUniversity of BrasiliaBrasilia-DFBrazil
  2. 2.Laboratory of Biochemistry and Protein Chemistry, Department of Cell Biology/IBUniversity of BrasiliaBrasilia-DFBrazil

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