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Multistage Vectors

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Encyclopedia of Nanotechnology

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Synonyms

Logic-embedded vectors; Multifunctional particles; Multistage delivery system; Third-generation vectors

Definition

Multistage vectors are multiparticle, multifunctional vectors strategically envisioned to overcome abundant obstacles encountered by drug delivery vectors as they journey from the site of administration to the target site. These vectors are comprised of layers of particles, with secondary nanoparticles and active agents nested into first-stage porous silicon microparticles. The ability to achieve sequential targeting through particle optimization enhances the probability of reaching the appropriate cellular or subcellular target within a lesion with the appropriate drug. Multistage vectors are a subset of Logic-Embedded Vectors (LEVs) [1]. By definition, LEVs are vectors with the ability to perform a time sequence of functions through the use of multiple nano-based components that synergistically provide distinct functionalities.

Porous Silicon Particles as...

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Author information

Authors and Affiliations

  1. Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    Rita E. Serda

  2. Department of NanoMedicine, Houston Methodist Research Institute, 6670 Bertner Avenue M.S. R7-414, Houston, TX, 77030, USA

    Rita E. Serda & Mauro Ferrari

Authors
  1. Rita E. Serda
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  2. Mauro Ferrari
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Corresponding author

Correspondence to Rita E. Serda .

Editor information

Editors and Affiliations

  1. Biomimetics (NLB²), Ohio State University Nanoprobe Lab. for Bio- & Nanotechnology, Columbus, Ohio, USA

    Bharat Bhushan

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Serda, R.E., Ferrari, M. (2015). Multistage Vectors. In: Bhushan, B. (eds) Encyclopedia of Nanotechnology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6178-0_78-2

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  • DOI: https://doi.org/10.1007/978-94-007-6178-0_78-2

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  • Publisher Name: Springer, Dordrecht

  • Online ISBN: 978-94-007-6178-0

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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